PMID- 9698830
OWN - NLM
STAT- MEDLINE
DCOM- 19981006
LR  - 20190516
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 31
IP  - 6
DP  - 1998 Jun
TI  - Changes in the TBARs content and superoxide dismutase, catalase and glutathione 
      peroxidase activities in the lymphoid organs and skeletal muscles of 
      adrenodemedullated rats.
PG  - 827-33
AB  - Thiobarbituric acid reactant substances (TBARs) content, and the activities of 
      glucose-6-phosphate dehydrogenase (G6PDh), citrate synthase (CS), Cu/Zn- and 
      Mn-superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) were 
      measured in the lymphoid organs (thymus, spleen, and mesenteric lymph nodes 
      (MLN)) and skeletal muscles (gastrocnemius and soleus) of adrenodemedullated 
      (ADM) rats. The results were compared with those obtained for sham-operated rats. 
      TBARs content was reduced by adrenodemedullation in the lymphoid organs (MLN) 
      (28%), thymus (40%) and spleen (42%)) and gastrocnemius muscle (67%). G6PDh 
      activity was enhanced in the MLN (69%) and reduced in the spleen (28%) and soleus 
      muscle (75%). CS activity was reduced in all tissues (MLN (75%), spleen (71%), 
      gastrocnemius (61%) and soleus (43%)), except in the thymus which displayed an 
      increment of 56%. Cu/Zn-SOD activity was increased in the MLN (126%), thymus 
      (223%), spleen (80%) and gastrocnemius muscle (360%) and was reduced in the 
      soleus muscle (31%). Mn-SOD activity was decreased in the MLN (67%) and spleen 
      (26%) and increased in the thymus (142%), whereas catalase activity was reduced 
      in the MLN (76%), thymus (54%) and soleus muscle (47%). It is particularly 
      noteworthy that in ADM rats the activity of glutathione peroxidase was not 
      detectable by the method used. These data are consistent with the possibility 
      that epinephrine might play a role in the oxidative stress of the lymphoid 
      organs. Whether this fact represents an important mechanism for the establishment 
      of impaired immune function during stress remains to be elucidated.
FAU - Pereira, B
AU  - Pereira B
AD  - Departamento de Biodinamica, Escola de Educacao Fisica e Esportes, Universidade 
      de Sao Paulo, Brasil.
FAU - Costa-Rosa, L F
AU  - Costa-Rosa LF
FAU - Bechara, E J
AU  - Bechara EJ
FAU - Newsholme, P
AU  - Newsholme P
FAU - Curi, R
AU  - Curi R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Adrenal Medulla/*surgery
MH  - Animals
MH  - Catalase/analysis/*metabolism
MH  - Glutathione Peroxidase/analysis/*metabolism
MH  - Lymph Nodes/metabolism
MH  - Lymphoid Tissue/*metabolism
MH  - Male
MH  - Mesentery/metabolism
MH  - Muscle, Skeletal/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Spleen/metabolism
MH  - Superoxide Dismutase/analysis/*metabolism
MH  - Thiobarbituric Acid Reactive Substances/analysis/*metabolism
MH  - Thymus Gland/metabolism
EDAT- 1998/08/12 00:00
MHDA- 1998/08/12 00:01
CRDT- 1998/08/12 00:00
PHST- 1998/08/12 00:00 [pubmed]
PHST- 1998/08/12 00:01 [medline]
PHST- 1998/08/12 00:00 [entrez]
AID - 10.1590/s0100-879x1998000600016 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 1998 Jun;31(6):827-33. doi: 10.1590/s0100-879x1998000600016.