PMID- 9699018
OWN - NLM
STAT- MEDLINE
DCOM- 19981026
LR  - 20191024
IS  - 0951-6433 (Print)
IS  - 0951-6433 (Linking)
VI  - 8
IP  - 1-2
DP  - 1998
TI  - Catechin metabolites after intake of green tea infusions.
PG  - 111-8
AB  - Green tea contains relatively large amounts of catechins, that have been 
      recognized to be efficient free-radical scavengers. In spite of a largely 
      described antioxidant effect, the metabolic fate of catechins in humans has been 
      scarcely studied. An infusion of green tea (about 400 mg of catechins) was given 
      to healthy volunteers; plasma and urine samples were collected for 5 h and 2 
      days, respectively. Epigallocatechin gallate and epicatechin gallate were 
      detected in plasma samples, reaching the maximum concentration (2 microM) at 2 h. 
      Urine samples collected at 6-48 h contained detectable amounts of final catechin 
      metabolites, including 4-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid, 
      3-methoxy-4-hydroxy-hippuric acid and 3-methoxy-4-hydroxybenzoic acid (vanillic 
      acid). The total content of these metabolites averaged 60 mg. The levels of free 
      plasma catechins account only partly for the increased (approximately +20%) total 
      radical-trapping antioxidant parameter (TRAP) detected after green tea intake. 
      Catechin conjugates (glucuronide and sulphate) and metabolites may add further 
      contribution and explain the measured TRAP increase.
FAU - Pietta, P G
AU  - Pietta PG
AD  - ITBA, CNR, Milan, Italy.
FAU - Simonetti, P
AU  - Simonetti P
FAU - Gardana, C
AU  - Gardana C
FAU - Brusamolino, A
AU  - Brusamolino A
FAU - Morazzoni, P
AU  - Morazzoni P
FAU - Bombardelli, E
AU  - Bombardelli E
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Biofactors
JT  - BioFactors (Oxford, England)
JID - 8807441
RN  - 0 (Antioxidants)
RN  - 0 (Benzoates)
RN  - 0 (Tea)
RN  - 8R1V1STN48 (Catechin)
RN  - 92587OVD8Z (epicatechin gallate)
RN  - BQM438CTEL (epigallocatechin gallate)
SB  - IM
MH  - Antioxidants/metabolism
MH  - Benzoates/urine
MH  - Catechin/*analogs & derivatives/blood/*pharmacokinetics/urine
MH  - Humans
MH  - *Tea
EDAT- 1998/08/12 00:00
MHDA- 1998/08/12 00:01
CRDT- 1998/08/12 00:00
PHST- 1998/08/12 00:00 [pubmed]
PHST- 1998/08/12 00:01 [medline]
PHST- 1998/08/12 00:00 [entrez]
AID - 10.1002/biof.5520080119 [doi]
PST - ppublish
SO  - Biofactors. 1998;8(1-2):111-8. doi: 10.1002/biof.5520080119.