PMID- 9700554
OWN - NLM
STAT- MEDLINE
DCOM- 19981013
LR  - 20191210
IS  - 1387-2273 (Print)
IS  - 1387-2273 (Linking)
VI  - 713
IP  - 1
DP  - 1998 Aug 21
TI  - Determination of drugs of abuse in blood.
PG  - 91-109
AB  - The detection and quantitation of drugs of abuse in blood is of growing interest 
      in forensic and clinical toxicology. With the development of highly sensitive 
      chromatographic methods, such as high-performance liquid chromatography (HPLC) 
      with sensitive detectors and gas chromatography-mass spectrometry (GC-MS), more 
      and more substances can be determined in blood. This review includes methods for 
      the determination of the most commonly occurring illicit drugs and their 
      metabolites, which are important for the assessment of drug abuse: 
      Methamphetamine, amphetamine, 3,4-methylenedioxymethamphetamine (MDMA), 
      N-ethyl-3,4-methylenedioxyamphetamine (MDEA), 3,4-methylenedioxy-amphetamine 
      (MDA), cannabinoids (delta-9-tetrahydrocannabinol, 
      11-hydroxy-delta-9-tetrahydrocannabinol, 
      11-nor-9-carboxy-delta-9-tetrahydrocannabinol), cocaine, benzoylecgonine, 
      ecgonine methyl ester, cocaethylene and the opiates (heroin, 
      6-monoacetylmorphine, morphine, codeine and dihydrocodeine). A number of 
      drugs/drug metabolites that are structurally close to these substances are 
      included in the tables. Basic information about the biosample assayed, work-up, 
      GC column or LC column and mobile phase, detection mode, reference data and 
      validation data of each procedure is summarized in the tables. Examples of 
      typical applications are presented.
FAU - Moeller, M R
AU  - Moeller MR
AD  - Institute of Legal Medicine, University of Saarland, Homburg (Saar), Germany.
FAU - Steinmeyer, S
AU  - Steinmeyer S
FAU - Kraemer, T
AU  - Kraemer T
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - J Chromatogr B Biomed Sci Appl
JT  - Journal of chromatography. B, Biomedical sciences and applications
JID - 9714109
RN  - 0 (Amphetamines)
RN  - 0 (Cannabinoids)
RN  - 0 (Designer Drugs)
RN  - 0 (Illicit Drugs)
RN  - 0 (Narcotics)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Amphetamines/blood
MH  - Cannabinoids/blood
MH  - Chromatography, Liquid/instrumentation/methods
MH  - Cocaine/blood
MH  - Designer Drugs/analysis
MH  - Gas Chromatography-Mass Spectrometry/instrumentation/methods
MH  - Humans
MH  - Illicit Drugs/*blood
MH  - Narcotics/blood
MH  - Substance Abuse Detection/*methods
RF  - 127
EDAT- 1998/08/13 00:00
MHDA- 1998/08/13 00:01
CRDT- 1998/08/13 00:00
PHST- 1998/08/13 00:00 [pubmed]
PHST- 1998/08/13 00:01 [medline]
PHST- 1998/08/13 00:00 [entrez]
AID - 10.1016/s0378-4347(97)00573-2 [doi]
PST - ppublish
SO  - J Chromatogr B Biomed Sci Appl. 1998 Aug 21;713(1):91-109. doi: 
      10.1016/s0378-4347(97)00573-2.