PMID- 9701255
OWN - NLM
STAT- MEDLINE
DCOM- 19980819
LR  - 20220318
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 66
IP  - 2
DP  - 1998 Jul 27
TI  - Effect of bioflavonoids quercetin and curcumin on ischemic renal injury: a new 
      class of renoprotective agents.
PG  - 147-52
AB  - BACKGROUND: Nonimmune renal injury plays an important role in acute and chronic 
      rejection by triggering an injury response through cytokine and chemokine 
      release. Bioflavonoids are agents with potential immunosuppressive and 
      renoprotective properties. We studied the effects of quercetin and curcumin, two 
      bioflavonoids, on ischemia-reperfusion in the rat. METHODS: Rats underwent 30 min 
      of left renal pedicle occlusion with simultaneous right nephrectomy and were 
      pretreated with quercetin or curcumin. Serial serum creatinine was measured, and 
      renal expression of the chemokines regulated upon activation, normal T-cell 
      expressed and secreted (RANTES), monocyte chemoattractant protein-1 (MCP-1), and 
      allograft inflammatory factor (AIF) was quantified by polymerase chain reaction. 
      RESULTS: Pretreatment with quercetin or curcumin resulted in preservation of 
      histological integrity, with a decrease in tubular damage and interstitial 
      inflammation. On day 2 after ischemia-reperfusion, quercetin pretreatment 
      decreased the mean serum creatinine level from 6.5+/-1.4 to 3.3+/-0.5 mg/dl 
      (P=0.06). On day 7, the creatinine level for control animals was 7.5+/-1.5 mg/dl, 
      which was significantly decreased by pretreatment with quercetin, curcumin, or 
      both together (creatinine levels: 1.6+/-1.3, 1.8+/-0.2, and 2.0+/-0.4 mg/dl, 
      respectively; all P<0.05 vs. untreated). By semiquantitative polymerase chain 
      reaction, RANTES, MCP-1, and AIF were detected at high levels in kidneys on day 2 
      but not in normal kidneys. Pretreatment with quercetin or curcumin strongly 
      attenuated this expression. CONCLUSION: Quercetin and curcumin reduce 
      ischemia-reperfusion injury and its inflammatory sequelae. The bioflavonoids hold 
      promise as agents that can reduce immune and nonimmune renal injury, the key risk 
      factors in chronic graft loss.
FAU - Shoskes, D A
AU  - Shoskes DA
AD  - Department of Surgery, Harbor-UCLA Medical Center, UCLA School of Medicine, 
      Torrance, California 90509, USA. dshoskes@ucla.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 9IKM0I5T1E (Quercetin)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/genetics
MH  - Chemokine CCL5/genetics
MH  - Curcumin/*pharmacology
MH  - Gene Expression/drug effects
MH  - Ischemia/*drug therapy/metabolism
MH  - Kidney/*blood supply
MH  - Male
MH  - Quercetin/*pharmacology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Reperfusion Injury/*prevention & control
EDAT- 1998/08/13 00:00
MHDA- 1998/08/13 00:01
CRDT- 1998/08/13 00:00
PHST- 1998/08/13 00:00 [pubmed]
PHST- 1998/08/13 00:01 [medline]
PHST- 1998/08/13 00:00 [entrez]
AID - 10.1097/00007890-199807270-00001 [doi]
PST - ppublish
SO  - Transplantation. 1998 Jul 27;66(2):147-52. doi: 10.1097/00007890-199807270-00001.