PMID- 9702056
OWN - NLM
STAT- MEDLINE
DCOM- 19981027
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 56
IP  - 7
DP  - 1998 Jul
TI  - [IL-18 and IL-18 receptor].
PG  - 1798-806
AB  - Interleukin-18 (IL-18) is a recently cloned cytokine, produced from activated 
      macrophages, including Kupffer cells. IL-18 is originally called interferon-gamma 
      inducing factor (IGIF), due to its action to induce IFN-gamma production from Th 
      1 cells and NK cells. However, recent studies suggested that, IL-18 also enhances 
      expression of FasL and NK activity as well as GM-CSF production. These data 
      revealed this novel cytokine is pleiotropic. Recently, cDNA encoding human IL-18 
      receptor (IL-18R) was cloned. And, we had cloned murine IL-18R cDNA by RT-PCR, 
      using human IL-18R sequence. Northern blot analysis of cytoplasmic RNA from T 
      cells stimulated with IL-12 clearly demonstrated that, T cells stimulated with 
      IL-12 induced high level of IL-18R-mRNA, whereas non-stimulated T cells did not 
      have. Interestingly, we had several reports, indicated the involvement of IL-18 
      on the progressions of pathogenicity in chronic inflammatory diseases, including 
      endotoxin-shock, hepatitis and autoimmune-diabetes. We need further studies to 
      reveal physiological roles of this novel cytokine in various inflammatory or 
      autoimmune diseases.
FAU - Kashiwamura, S
AU  - Kashiwamura S
AD  - Laboratory of Host Defenses, Hyogo College of Medicine.
FAU - Okamura, H
AU  - Okamura H
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (FASLG protein, human)
RN  - 0 (Fas Ligand Protein)
RN  - 0 (IL18R1 protein, human)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-18 Receptor alpha Subunit)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (Receptors, Interleukin-18)
RN  - 187348-17-0 (Interleukin-12)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/etiology
MH  - Fas Ligand Protein
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/metabolism
MH  - Hepatitis/etiology
MH  - Humans
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-12/immunology
MH  - *Interleukin-18/genetics/physiology
MH  - Interleukin-18 Receptor alpha Subunit
MH  - Membrane Glycoproteins/metabolism
MH  - *Receptors, Interleukin/physiology
MH  - Receptors, Interleukin-18
MH  - Signal Transduction
MH  - T-Lymphocytes/immunology/metabolism
RF  - 36
EDAT- 1998/08/14 00:00
MHDA- 1998/08/14 00:01
CRDT- 1998/08/14 00:00
PHST- 1998/08/14 00:00 [pubmed]
PHST- 1998/08/14 00:01 [medline]
PHST- 1998/08/14 00:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 1998 Jul;56(7):1798-806.