PMID- 9702539
OWN - NLM
STAT- MEDLINE
DCOM- 19981027
LR  - 20190921
IS  - 1043-3074 (Print)
IS  - 1043-3074 (Linking)
VI  - 20
IP  - 6
DP  - 1998 Sep
TI  - Characterizing the antigenic profile of the human trachea: implications for 
      tracheal transplantation.
PG  - 522-7
AB  - BACKGROUND: Tracheal transplantation may be a viable alternative in select 
      situations of long-segment tracheal stenosis. Issues concerning human tracheal 
      antigenicity and the requirement for systemic immunosuppression need to be 
      addressed. This study examined the distribution of the major transplantation 
      antigens on fresh human trachea. METHODS: Frozen sections of 10 human tracheas 
      were examined for class I (HLA [human leukocyte antigen]-A, -B, -C) and class II 
      (HLA-DR) histocompatibility antigens using mouse monoclonal antibodies in an 
      indirect immunoperoxidase assay. The tracheal mucosa, perichondrium, cartilage 
      matrix, and chondrocytes were examined and assigned a semiquantitative score for 
      HLA class I and class II expression. RESULTS: The tracheal mucosa was strongly 
      antigenic for HLA class I and class II antigens, whereas the perichondrium 
      contained only scattered fibroblasts that were positive for both classes. The 
      polysaccharide matrix was consistently devoid of class I or class II expression. 
      The chondrocytes of all 10 specimens expressed diffuse class I positivity; only 
      two specimens contained chondrocytes that expressed class II positivity. 
      CONCLUSIONS: The human trachea contains "compartments" of highly antigenic tissue 
      that are morphologically distinct from regions of lesser antigenicity.
FAU - Shaari, C M
AU  - Shaari CM
AD  - Department of Otolaryngology, Mount Sinai School of Medicine, New York, New York 
      10029, USA.
FAU - Farber, D
AU  - Farber D
FAU - Brandwein, M S
AU  - Brandwein MS
FAU - Gannon, P
AU  - Gannon P
FAU - Urken, M L
AU  - Urken ML
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Biopsy
MH  - Culture Techniques
MH  - Histocompatibility Antigens Class I/*analysis
MH  - Histocompatibility Antigens Class II/*analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Reference Values
MH  - Sensitivity and Specificity
MH  - Trachea/*immunology/pathology/transplantation
EDAT- 1998/08/14 02:01
MHDA- 2000/06/20 09:00
CRDT- 1998/08/14 02:01
PHST- 1998/08/14 02:01 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1998/08/14 02:01 [entrez]
AID - 10.1002/(SICI)1097-0347(199809)20:6<522::AID-HED6>3.0.CO;2-O [pii]
AID - 10.1002/(sici)1097-0347(199809)20:6<522::aid-hed6>3.0.co;2-o [doi]
PST - ppublish
SO  - Head Neck. 1998 Sep;20(6):522-7. doi: 
      10.1002/(sici)1097-0347(199809)20:6<522::aid-hed6>3.0.co;2-o.