PMID- 9703202
OWN - NLM
STAT- MEDLINE
DCOM- 19981021
LR  - 20190826
IS  - 0306-3623 (Print)
IS  - 0306-3623 (Linking)
VI  - 31
IP  - 3
DP  - 1998 Sep
TI  - Inhibition of mast cell-dependent anaphylactic reactions by the pigment of 
      Polygonum tinctorium (Chung-Dae) in rats.
PG  - 361-5
AB  - 1. The effect of the pigment obtained from the stem and leaf of Polygonum 
      tinctorium Loar (PtP) on anaphylactic reactions was studied in rats. 2. PtP 
      totally inhibited compound 48/80-induced anaphylactic shock with doses of 10(2) 
      and 10(3) mg/ kg. When PtP was pretreated at concentrations ranging from 10(-2) 
      to 10(3) mg/kg, the serum histamine levels induced by compound 48/80 were reduced 
      in a dose-dependent manner. 3. We also investigated the effect of PtP on mast 
      cell-dependent passive cutaneous anaphylaxis (PCA) activated by 
      anti-dinitrophenyl (DNP) IgE antibody. PtP potently inhibited PCA when 
      administered orally, topically, intraperitoneally and intradermally. However, it 
      did not show inhibitory activity when administered intravenously. 4. PtP 
      inhibited dose dependently histamine release from rat peritoneal mast cells 
      (RPMCs) induced by compound 48/80 and anti-DNP IgE. Moreover, the level of cAMP 
      in RPMC, when PtP was added, significantly increased about 12-fold at 4 min 
      compared with that of basal cells. 5. These results indicate that PtP may possess 
      strong antianaphylactic activity and suggest that differences in bioavailability 
      may cause differential activity following different administration routes.
FAU - Kim, H M
AU  - Kim HM
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, 
      Chonbuk, South Korea. hmkim@med.wonkwang.ac.kr
FAU - Hong, D R
AU  - Hong DR
FAU - Lee, E H
AU  - Lee EH
LA  - eng
PT  - Journal Article
PL  - England
TA  - Gen Pharmacol
JT  - General pharmacology
JID - 7602417
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Pigments, Biological)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Anaphylaxis/chemically induced/*prevention & control
MH  - Animals
MH  - Cyclic AMP/metabolism
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Female
MH  - Histamine Release/drug effects
MH  - Immunoglobulin E
MH  - Male
MH  - Mast Cells/*drug effects/physiology
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Pigments, Biological/*pharmacology/therapeutic use
MH  - Plants, Medicinal
MH  - Polygonaceae/*chemistry
MH  - Rats
MH  - p-Methoxy-N-methylphenethylamine/antagonists & inhibitors/pharmacology
EDAT- 1998/08/14 00:00
MHDA- 1998/08/14 00:01
CRDT- 1998/08/14 00:00
PHST- 1998/08/14 00:00 [pubmed]
PHST- 1998/08/14 00:01 [medline]
PHST- 1998/08/14 00:00 [entrez]
AID - S0306362398000421 [pii]
AID - 10.1016/s0306-3623(98)00042-1 [doi]
PST - ppublish
SO  - Gen Pharmacol. 1998 Sep;31(3):361-5. doi: 10.1016/s0306-3623(98)00042-1.