PMID- 9703224
OWN - NLM
STAT- MEDLINE
DCOM- 19981021
LR  - 20190826
IS  - 0306-3623 (Print)
IS  - 0306-3623 (Linking)
VI  - 31
IP  - 3
DP  - 1998 Sep
TI  - Action of Ulmi radicis cortex extract on systemic and local anaphylaxis in rats.
PG  - 483-8
AB  - 1. To assess the contribution of an aqueous extract of Ulmi radicis cortex 
      (AEURC) in systemic anaphylaxis, compound 48/80 was used as a fatal anaphylaxis 
      inducer in rats. 2. AEURC completely inhibited anaphylactic shock with a dose of 
      1.0 g/kg body weight (BW) 1 hr before injection of compound 48/80. 3. AEURC 
      significantly inhibited serum histamine levels induced by compound 48/80. 4. 
      AEURC (1.0 g/kg BW) also inhibited by 79.1% passive cutaneous anaphylaxis 
      activated by anti-dinitrophenyl (DNP) IgE. 5. AEURC dose dependently inhibited 
      the histamine release from the rat peritoneal mast cells (RPMCs) by compound 
      48/80. Moreover, AEURC had a significant inhibitory effect on anti-DNP 
      IgE-induced histamine release and tumor necrosis factor-alpha production from 
      RPMC. 6. The level of cAMP in RPMC, when AEURC was added, significantly increased 
      compared with that of a normal control. 7. These results indicate that AEURC may 
      possess strong antianaphylactic action.
FAU - Kim, H M
AU  - Kim HM
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, 
      Chonbuk, South Korea. hmkim@med.wonkwang.ac.kr
FAU - Shin, H Y
AU  - Shin HY
FAU - Choi, I Y
AU  - Choi IY
FAU - Lee, E H
AU  - Lee EH
FAU - Lee, E J
AU  - Lee EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Gen Pharmacol
JT  - General pharmacology
JID - 7602417
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (anti-IgE antibodies)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Anaphylaxis/chemically induced/*prevention & control
MH  - Animals
MH  - Antibodies, Anti-Idiotypic
MH  - Cyclic AMP/metabolism
MH  - Female
MH  - Histamine Release/drug effects
MH  - Korea
MH  - Male
MH  - Mast Cells/drug effects/metabolism
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Plant Extracts/*pharmacology/therapeutic use
MH  - Plants, Medicinal/chemistry
MH  - Rats
MH  - Tumor Necrosis Factor-alpha/biosynthesis/drug effects
MH  - p-Methoxy-N-methylphenethylamine
EDAT- 1998/08/14 00:00
MHDA- 1998/08/14 00:01
CRDT- 1998/08/14 00:00
PHST- 1998/08/14 00:00 [pubmed]
PHST- 1998/08/14 00:01 [medline]
PHST- 1998/08/14 00:00 [entrez]
AID - S0306362398000032 [pii]
AID - 10.1016/s0306-3623(98)00003-2 [doi]
PST - ppublish
SO  - Gen Pharmacol. 1998 Sep;31(3):483-8. doi: 10.1016/s0306-3623(98)00003-2.