PMID- 9705018
OWN - NLM
STAT- MEDLINE
DCOM- 19980901
LR  - 20191024
VI  - 22
IP  - 7
DP  - 1998 Jul
TI  - Differences in energy expenditure and substrate oxidation between habitual high 
      fat and low fat consumers (phenotypes).
PG  - 612-8
AB  - OBJECTIVE: To investigate physiological differences between habitual high-fat 
      (HF) and low-fat (LF) consumers, which could influence the balance between energy 
      expenditure and energy intake, and the potential for weight gain. SUBJECTS: 16 
      young, lean males (eight HF and eight LF consumers; % energy from fat 44.3 and 
      32.0, respectively). MEASUREMENTS: Habitual dietary variables (from FFQ), body 
      mass index (BMI), body fat % (measured by impedance), resting metabolic rate 
      (RMR) (indirect calorimetry), substrate oxidation and basal heart rate, 
      postprandial thermogenesis and heart rate in response to a high-fat (low 
      carbohydrate (CHO)) and high-CHO (low fat) challenge. RESULTS: HF and LF 
      (selected for their intake of fat) did not differ significantly in BMI or % body 
      fat. HF had a significantly higher RMR (1624 vs 1455 kcal/d) and basal heart rate 
      (66 vs 57 bpm) than LF. Differences in oxygen utilisation and heart rate were 
      maintained over a 180 min period, following the high-fat and high-CHO challenge 
      meals. HF had a significantly lower resting respiratory quotient (RQ) than LF and 
      the differences in average RQ were significant over the 180 min examination 
      period. HF had a significantly lower RQ response to the high fat (low CHO) than 
      to the high CHO (low fat) challenge; this effect was not observed in LF. HF had 
      higher total energy intake than LF and a higher absolute (but not %) intake of 
      protein. CONCLUSION: Significant differences in basal energy expenditure and fat 
      oxidation between habitual HF and LF consumers have been observed. The 
      contributions of energy intake and protein intake (g not %) remain to be 
      determined. In this particular group of subjects (young adult males) a high 
      energy intake characterised by a large fat component is associated with metabolic 
      adaptations which could offset the weight inducing properties of a high-fat diet. 
      These physiological differences may be important when considering the 
      relationship between dietary-fat and obesity.
FAU - Cooling, J
AU  - Cooling J
AD  - Department of Psychology, University of Leeds, UK.
FAU - Blundell, J
AU  - Blundell J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Obes Relat Metab Disord
JT  - International journal of obesity and related metabolic disorders : journal of the 
      International Association for the Study of Obesity
JID - 9313169
RN  - 0 (Dietary Fats)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Body Composition
MH  - Dietary Fats/*administration & dosage
MH  - Energy Intake
MH  - *Energy Metabolism
MH  - Feeding Behavior
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Oxidation-Reduction
MH  - Phenotype
MH  - Weight Gain
EDAT- 1998/08/15 00:00
MHDA- 1998/08/15 00:01
CRDT- 1998/08/15 00:00
PHST- 1998/08/15 00:00 [pubmed]
PHST- 1998/08/15 00:01 [medline]
PHST- 1998/08/15 00:00 [entrez]
AID - 10.1038/sj.ijo.0800635 [doi]
PST - ppublish
SO  - Int J Obes Relat Metab Disord. 1998 Jul;22(7):612-8. doi: 10.1038/sj.ijo.0800635.