PMID- 9705834
OWN - NLM
STAT- MEDLINE
DCOM- 19980917
LR  - 20041117
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 249
IP  - 1
DP  - 1998 Aug 10
TI  - Up-regulation of vascular endothelial growth factor induced by hepatocyte growth 
      factor/scatter factor stimulation in human glioma cells.
PG  - 73-7
AB  - Recent findings suggest that hepatocyte growth factor/scatter factor (HGF/SF) 
      contributes to the malignant progression of human gliomas. We investigated the 
      effect of HGF/SF on vascular endothelial growth factor (VEGF) expression of 
      c-Met/HGF receptor-positive human glioma cell lines. Treatment of the glioma 
      cells with various concentrations of HGF/SF resulted in an enhanced secretion of 
      VEGF proteins accompanying increased transcription of VEGF mRNA in a 
      dose-dependent fashion. Since malignant gliomas frequently co-express HGF/SF and 
      its receptor, these results suggest that HGF/SF could act as an indirect 
      angiogenic factor through autocrine induction of VEGF expression and secretion in 
      malignant gliomas.
FAU - Moriyama, T
AU  - Moriyama T
AD  - Department of Neurosurgery, Miyazaki Medical College, Japan. 
      nstm@post.miyazaki-med.ac.jp
FAU - Kataoka, H
AU  - Kataoka H
FAU - Hamasuna, R
AU  - Hamasuna R
FAU - Yokogami, K
AU  - Yokogami K
FAU - Uehara, H
AU  - Uehara H
FAU - Kawano, H
AU  - Kawano H
FAU - Goya, T
AU  - Goya T
FAU - Tsubouchi, H
AU  - Tsubouchi H
FAU - Koono, M
AU  - Koono M
FAU - Wakisaka, S
AU  - Wakisaka S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Endothelial Growth Factors)
RN  - 0 (Lymphokines)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factors)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Endothelial Growth Factors/*biosynthesis
MH  - Glioma/*metabolism
MH  - Hepatocyte Growth Factor/*pharmacology
MH  - Humans
MH  - Lymphokines/*biosynthesis
MH  - Tumor Cells, Cultured
MH  - Up-Regulation/drug effects
MH  - Vascular Endothelial Growth Factor A
MH  - Vascular Endothelial Growth Factors
EDAT- 1998/08/26 00:00
MHDA- 1998/08/26 00:01
CRDT- 1998/08/26 00:00
PHST- 1998/08/26 00:00 [pubmed]
PHST- 1998/08/26 00:01 [medline]
PHST- 1998/08/26 00:00 [entrez]
AID - S0006-291X(98)99078-7 [pii]
AID - 10.1006/bbrc.1998.9078 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1998 Aug 10;249(1):73-7. doi: 10.1006/bbrc.1998.9078.