PMID- 9706422
OWN - NLM
STAT- MEDLINE
DCOM- 19981023
LR  - 20170112
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 16
IP  - 4
DP  - 1998 Jul-Aug
TI  - HLA-DRB1 alleles and beta 2 glycoprotein I-dependent anticardiolipin antibodies 
      in Japanese patients with systemic lupus erythematosus.
PG  - 423-7
AB  - OBJECTIVE: To investigate the association of HLA DRB1 alleles with beta 2 
      glycoprotein I (beta 2 GPI)-dependent anticardiolipin antibodies (aCL) in 
      Japanese patients with systemic lupus erythematosus (SLE). METHODS: One hundred 
      and forty-five Japanese patients with SLE were studied. beta 2 GPI-dependent aCL 
      was measured by enzyme-linked immunosorbent assays. DNA typing of the DRB1 
      alleles was performed by the polymerase chain reaction sequence specific 
      oligonucleotide probe method. RESULTS: beta 2 GPI-dependent aCL was positive in 
      29 (20.0%) out of 145 SLE patients. SLE patients with beta 2 GPI-dependent aCL 
      had a significantly higher frequency or one or more of the clinical 
      manifestations assumed to be associated with aCL, compared to those without beta 
      2 GPI-dependent aCL (p < 0.05). The frequency of DRB1*0901 was lower in SLE 
      patients than in healthy subjects. SLE patients with beta 2 GPI-dependent aCL 
      were significantly associated with DRB1*0901 as compared to those without beta 2 
      GPI-dependent aCL (41.4% vs 15.5%, p < 0.005, R.R. = 3.8), although the corrected 
      P value was not significant. CONCLUSION: A possible association of DRB1*0901 with 
      Japanese SLE patients with beta 2 GPI-dependent aCL was found. This association 
      indicates an association between the disease and the HLA-DR53 (DRB4)-bearing 
      haplotypes in different ethnic groups.
FAU - Hashimoto, H
AU  - Hashimoto H
AD  - Department of Internal Medicine and Rheumatology, Juntendo University, Tokyo, 
      Japan.
FAU - Yamanaka, K
AU  - Yamanaka K
FAU - Tokano, Y
AU  - Tokano Y
FAU - Iida, N
AU  - Iida N
FAU - Takasaki, Y
AU  - Takasaki Y
FAU - Kabasawa, K
AU  - Kabasawa K
FAU - Nishimura, Y
AU  - Nishimura Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (Antibodies, Anticardiolipin)
RN  - 0 (Glycoproteins)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (beta 2-Glycoprotein I)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Alleles
MH  - Antibodies, Anticardiolipin/*analysis
MH  - Antiphospholipid Syndrome/genetics/immunology/pathology
MH  - DNA/analysis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Glycoproteins/*immunology
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/genetics/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Japan/epidemiology
MH  - Lupus Erythematosus, Systemic/epidemiology/*genetics/*immunology
MH  - Polymerase Chain Reaction
MH  - beta 2-Glycoprotein I
EDAT- 1998/08/26 00:00
MHDA- 1998/08/26 00:01
CRDT- 1998/08/26 00:00
PHST- 1998/08/26 00:00 [pubmed]
PHST- 1998/08/26 00:01 [medline]
PHST- 1998/08/26 00:00 [entrez]
PST - ppublish
SO  - Clin Exp Rheumatol. 1998 Jul-Aug;16(4):423-7.