PMID- 9708794
OWN - NLM
STAT- MEDLINE
DCOM- 19980825
LR  - 20240214
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 153
IP  - 2
DP  - 1998 Aug
TI  - Differential expression of the peroxisome proliferator-activated receptor gamma 
      (PPARgamma) and its coactivators steroid receptor coactivator-1 and PPAR-binding 
      protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse.
PG  - 349-54
AB  - Peroxisome proliferator-activated receptors (PPARs) regulate genes involved in 
      lipid metabolism and adipocyte differentiation. Steroid receptor coactivator-1 
      (SRC-1) and PPAR-binding protein (PBP) interact with PPARgamma and act as 
      coactivators to enhance ligand-dependent transcription. We report here that 
      PPARgamma, SRC-1, and PBP are differentially expressed in the brown fat, 
      transitional epithelium of the urinary bladder, colonic mucosa, and mammary 
      epithelium of the adult mouse. PPARgamma and PBP are expressed in the 
      transitional epithelium of urinary bladder and in brown adipose tissue, but not 
      SRC-1. In the colonic mucosa, PPARgamma expression occurs throughout the villi, 
      whereas the expression of both SRC-1 and PBP is confined mostly to the crypts. 
      The expression of both SRC-1 and PBP is prominent in the breast epithelium of 
      nonpregnant, pregnant, and lactating mice, whereas PPARgamma expression appeared 
      prominent during lactation. During early embryonic development, PPARgamma, SRC-1, 
      and PBP are differentially expressed, with only limited cell types displaying 
      overlapping expression. PPARgamma and PBP expression overlapped in the brown fat 
      and urogenital sinus at stage E15.5 of embryogenesis, whereas SRC-1 expression 
      occurred mostly in neuroepithelium and cartilage between stages E9.5 and E13.5 of 
      embryogenesis.
FAU - Jain, S
AU  - Jain S
AD  - Department of Pathology, Northwestern University Medical School, Chicago, 
      Illinois 60611, USA.
FAU - Pulikuri, S
AU  - Pulikuri S
FAU - Zhu, Y
AU  - Zhu Y
FAU - Qi, C
AU  - Qi C
FAU - Kanwar, Y S
AU  - Kanwar YS
FAU - Yeldandi, A V
AU  - Yeldandi AV
FAU - Rao, M S
AU  - Rao MS
FAU - Reddy, J K
AU  - Reddy JK
LA  - eng
GR  - R01 GM023750/GM/NIGMS NIH HHS/United States
GR  - R37 GM023750/GM/NIGMS NIH HHS/United States
GR  - GM-23750/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Carrier Proteins)
RN  - 0 (Med1 protein, mouse)
RN  - 0 (Mediator Complex Subunit 1)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Transcription Factors)
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
RN  - EC 2.3.1.48 (Ncoa1 protein, mouse)
RN  - EC 2.3.1.48 (Nuclear Receptor Coactivator 1)
SB  - IM
MH  - Adipose Tissue, Brown/metabolism
MH  - Animals
MH  - Carrier Proteins/*metabolism
MH  - Colon/metabolism
MH  - Embryo, Mammalian/metabolism
MH  - Female
MH  - Gene Expression
MH  - Gene Expression Regulation, Developmental
MH  - Histone Acetyltransferases
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Intestinal Mucosa/metabolism
MH  - Lactation/*metabolism
MH  - Mammary Glands, Animal/metabolism
MH  - Mediator Complex Subunit 1
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nuclear Receptor Coactivator 1
MH  - Pregnancy
MH  - Pregnancy, Animal/*metabolism
MH  - Receptors, Cytoplasmic and Nuclear/*metabolism
MH  - Time Factors
MH  - Tissue Distribution
MH  - Transcription Factors/*metabolism
MH  - Urinary Bladder/metabolism
PMC - PMC1852994
EDAT- 1998/08/26 00:00
MHDA- 1998/08/26 00:01
PMCR- 1999/02/01
CRDT- 1998/08/26 00:00
PHST- 1998/08/26 00:00 [pubmed]
PHST- 1998/08/26 00:01 [medline]
PHST- 1998/08/26 00:00 [entrez]
PHST- 1999/02/01 00:00 [pmc-release]
AID - S0002-9440(10)65577-0 [pii]
AID - 1366 [pii]
AID - 10.1016/s0002-9440(10)65577-0 [doi]
PST - ppublish
SO  - Am J Pathol. 1998 Aug;153(2):349-54. doi: 10.1016/s0002-9440(10)65577-0.