PMID- 9709918
OWN - NLM
STAT- MEDLINE
DCOM- 19981029
LR  - 20071115
IS  - 1050-7256 (Print)
IS  - 1050-7256 (Linking)
VI  - 8
IP  - 7
DP  - 1998 Jul
TI  - What is the evidence of genetic factors in the etiology of Graves' disease? A 
      brief review.
PG  - 627-34
AB  - Graves' disease (GD) is generally thought of as a multifactorial disorder in 
      which genetic susceptibility interacts with environmental and endogenous factors 
      to cause disease. The importance of genetic factors is suggested by the 
      clustering of GD within families and by a higher concordance rate for disease in 
      monozygotic than in dizygotic twins. This has, however, recently been shown to be 
      less pronounced than previously thought. During the last decade much effort has 
      been put into characterization of the genetic background of GD. Until recently, 
      most studies have examined associations between GD and the human leukocyte 
      antigen (HLA) region, but recent advances in molecular techniques have opened the 
      way for whole genome screening. A number of HLA and non-HLA candidate genes have 
      been proposed, but despite several large investigations within multiplex families 
      no major susceptibility genes have been identified. This brief review discusses 
      relevant articles published from 1940 through 1997 regarding the influence of 
      genetic factors in the etiology of GD. Ongoing studies focus on whole genome 
      screening in multiplex families as well as population-based twin studies. 
      However, the possibility of GD being a heterogeneous disease without a single 
      well-defined genotype and phenotype should be left open.
FAU - Brix, T H
AU  - Brix TH
AD  - Department of Endocrinology M, Odense University Hospital, Odense C, Denmark.
FAU - Kyvik, K O
AU  - Kyvik KO
FAU - Hegedus, L
AU  - Hegedus L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Genetic Markers
MH  - *Genetic Predisposition to Disease
MH  - Graves Disease/*genetics
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Twin Studies as Topic
RF  - 86
EDAT- 1998/08/26 00:00
MHDA- 1998/08/26 00:01
CRDT- 1998/08/26 00:00
PHST- 1998/08/26 00:00 [pubmed]
PHST- 1998/08/26 00:01 [medline]
PHST- 1998/08/26 00:00 [entrez]
AID - 10.1089/thy.1998.8.627 [doi]
PST - ppublish
SO  - Thyroid. 1998 Jul;8(7):627-34. doi: 10.1089/thy.1998.8.627.