PMID- 9709923
OWN - NLM
STAT- MEDLINE
DCOM- 19980902
LR  - 20061115
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 83
IP  - 8
DP  - 1998 Aug
TI  - Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation 
      of the MEN1 gene in sporadic pituitary adenomas.
PG  - 2631-4
AB  - To investigate the role of tumor suppressor genes in sporadic pituitary adenomas, 
      we first analyzed loss of heterozygosity on 11q13 with microsatellite analysis in 
      31 tumors. Loss of heterozygosity on 11q13 was detected in 1 mixed GH/PRL 
      adenoma, and the somatic 22-bp deletion of the multiple endocrine neoplasia type 
      1 (MEN1) gene encoding menin was detected in this tumor. Trisomy 11 suggested by 
      the decreased mean allelic ratios of 66% or 65% for 16 or 13 microsatellite 
      markers, respectively, in 2 of 31 pituitary adenomas was confirmed by interphase 
      fluorescence in situ hybridization. Screening for mutations of the MEN1 gene did 
      not find mutations with PCR-single strand conformation polymorphism analysis in 
      other pituitary adenomas retaining heterozygosity on 11q13. Based on these, it is 
      concluded that inactivation of the MEN1 gene comprises a rare etiology for 
      tumorigenesis of the pituitary gland, and that trisomy 11 or another gene(s) may 
      contribute to the pathogenesis of sporadic pituitary adenomas.
FAU - Tanaka, C
AU  - Tanaka C
AD  - Otsuka Department of Clinical and Molecular Nutrition, University of Tokushima 
      School of Medicine, Japan.
FAU - Kimura, T
AU  - Kimura T
FAU - Yang, P
AU  - Yang P
FAU - Moritani, M
AU  - Moritani M
FAU - Yamaoka, T
AU  - Yamaoka T
FAU - Yamada, S
AU  - Yamada S
FAU - Sano, T
AU  - Sano T
FAU - Yoshimoto, K
AU  - Yoshimoto K
FAU - Itakura, M
AU  - Itakura M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
CIN - J Clin Endocrinol Metab. 1998 Aug;83(8):2617-20. PMID: 9709920
MH  - Adenoma/*genetics
MH  - Alleles
MH  - *Chromosomes, Human, Pair 11
MH  - Genes, Tumor Suppressor
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Loss of Heterozygosity
MH  - Microsatellite Repeats
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Pituitary Neoplasms/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single-Stranded Conformational
MH  - Trisomy
EDAT- 1998/08/26 00:00
MHDA- 1998/08/26 00:01
CRDT- 1998/08/26 00:00
PHST- 1998/08/26 00:00 [pubmed]
PHST- 1998/08/26 00:01 [medline]
PHST- 1998/08/26 00:00 [entrez]
AID - 10.1210/jcem.83.8.4888 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1998 Aug;83(8):2631-4. doi: 10.1210/jcem.83.8.4888.