PMID- 9709952
OWN - NLM
STAT- MEDLINE
DCOM- 19980902
LR  - 20151119
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 83
IP  - 8
DP  - 1998 Aug
TI  - Mechanisms of whole-body glycogen deposition after oral glucose in normal 
      subjects. Influence of the nutritional status.
PG  - 2810-6
AB  - It is known that prior fasting enhances whole-body glycogen retention after 
      glucose ingestion. To identify the involved mechanisms, 33 normal volunteers 
      underwent a total fast, varying between 14 h and 4 days, and ingested thereafter 
      75 g glucose labeled with [14C]glucose. Measurements of oral glucose oxidation 
      (expired 14CO2, corrected for incomplete recovery) and total carbohydrate (CHO) 
      oxidation (indirect calorimetry) were performed over the following 5 h. These 
      data allowed us to calculate oral glucose storage (uptake oxidation), glycogen 
      oxidation (CHO oxidation - oral glucose oxidation), and net CHO balance (oral 
      glucose uptake - CHO oxidation). As compared with an overnight fast, prolonged 
      fasting (4 days) inhibited the uptake (64.8 vs. 70.3 g/5 h; P < 0.01) and the 
      oxidation (10.9 vs. 20.0 g/5 h; P < 0.001) of oral glucose and stimulated 
      slightly its conversion to glycogen (53.9 vs. 50.3 g/5 h; P < 0.05). The latter 
      effect played only a minor role in the marked increase in net CHO balance (52.3 
      vs. 25.2 g/5 h; P < 0.001), which was almost entirely related to a decrease in 
      glycogen oxidation (1.6 vs. 25.1 g/5 h; P < 0.001). Considering the whole series 
      of data, including intermediate durations of fast, it was observed that the 
      modifications in postprandial CHO metabolism, induced by fasting, correlated 
      strongly with basal CHO oxidation, suggesting that the degree of initial glycogen 
      depletion is a major determinant of glycogen oxidation and net CHO storage. Thus, 
      prior fasting stimulates postprandial glycogen retention, mainly through an 
      inhibition of the glycogen turnover that exists in overnight-fasted subjects, 
      during the absorptive period.
FAU - Fery, F
AU  - Fery F
AD  - Department of Endocrinology, Erasmus Hospital, University of Brussels, Belgium.
FAU - Plat, L
AU  - Plat L
FAU - Balasse, E O
AU  - Balasse EO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Carbon Radioisotopes)
RN  - 0 (Dietary Carbohydrates)
RN  - 142M471B3J (Carbon Dioxide)
RN  - 9005-79-2 (Glycogen)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Breath Tests
MH  - Calorimetry, Indirect
MH  - Carbohydrate Metabolism
MH  - Carbon Dioxide/analysis
MH  - Carbon Radioisotopes
MH  - Dietary Carbohydrates/administration & dosage/metabolism
MH  - Fasting
MH  - Glucose/*administration & dosage
MH  - Glucose Tolerance Test
MH  - Glycogen/*metabolism
MH  - Humans
MH  - Kinetics
MH  - Male
MH  - *Nutritional Status
MH  - Oxidation-Reduction
EDAT- 1998/08/26 00:00
MHDA- 1998/08/26 00:01
CRDT- 1998/08/26 00:00
PHST- 1998/08/26 00:00 [pubmed]
PHST- 1998/08/26 00:01 [medline]
PHST- 1998/08/26 00:00 [entrez]
AID - 10.1210/jcem.83.8.5022 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1998 Aug;83(8):2810-6. doi: 10.1210/jcem.83.8.5022.