PMID- 9710047
OWN - NLM
STAT- MEDLINE
DCOM- 19980908
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 51
IP  - 2
DP  - 1998 Aug
TI  - A loss of functional spinal alpha motor neurons in amyotrophic lateral sclerosis.
PG  - 603-5
AB  - We obtained motor unit number estimates (MUNEs) of the hypothenar and the 
      extensor digitorum brevis muscles in ALS patients by our new technique. One year 
      after symptom onset, the MUNEs had decreased to +/-30% of normal. Accordingly, we 
      suggest that 70% of functional spinal alpha motor neurons are lost in the first 
      post-onset year in ALS.
FAU - Arasaki, K
AU  - Arasaki K
AD  - Department of Neurology, NTT Kanto Teishin Hospital, Tokyo, Japan.
FAU - Tamaki, M
AU  - Tamaki M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amyotrophic Lateral Sclerosis/*pathology
MH  - Case-Control Studies
MH  - Humans
MH  - Middle Aged
MH  - Motor Neurons/*physiology
MH  - Reproducibility of Results
MH  - Spinal Cord/*cytology
EDAT- 1998/08/26 00:00
MHDA- 1998/08/26 00:01
CRDT- 1998/08/26 00:00
PHST- 1998/08/26 00:00 [pubmed]
PHST- 1998/08/26 00:01 [medline]
PHST- 1998/08/26 00:00 [entrez]
AID - 10.1212/wnl.51.2.603 [doi]
PST - ppublish
SO  - Neurology. 1998 Aug;51(2):603-5. doi: 10.1212/wnl.51.2.603.