PMID- 9710230
OWN - NLM
STAT- MEDLINE
DCOM- 19980903
LR  - 20180512
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 28
IP  - 8
DP  - 1998 Aug
TI  - Tumor-driven matrix invasion by infiltrating lymphocytes: involvement of the 
      alpha1 integrin I-domain.
PG  - 2530-6
AB  - Here we show that tumor cells (TC) from renal cancers regulate the migratory 
      properties of autologous tumor-infiltrating lymphocytes (TIL), enhancing their 
      ability to invade the extracellular matrix. A similar effect is exerted by human 
      recombinant macrophage chemotactic protein 1 (MCP-1) and IL-8, chemokines known 
      to increase T lymphocyte migration both across vascular endothelium and 
      subendothelial matrix. We found that TC freshly derived from renal cell carcinoma 
      surgical specimens constitutively secrete both IL-8 and MCP-1 and that TIL 
      express both specific receptors. TIL matrix invasion elicited by TC is inhibited 
      by the addition of neutralizing antisera specific for IL-8 and MCP-1, 
      demonstrating the direct relationship between chemokine release by TC and TIL 
      invasion. Of note, TIL invasion of the extracellular matrix requires the alpha1 
      integrin, which acts through its I-domain that is upregulated upon culture with 
      MCP-1 and IL-8. Collectively, these findings suggest that TC may actively recruit 
      TIL via the release of chemotactic factors that enhance an alpha1 
      integrin-mediated pathway of matrix invasion.
FAU - Ferrero, E
AU  - Ferrero E
AD  - Laboratory of Tumor Immunology, Scientific Institute of San Raffaele, Milan, 
      Italy.
FAU - Fabbri, M
AU  - Fabbri M
FAU - Poggi, A
AU  - Poggi A
FAU - Galati, G
AU  - Galati G
FAU - Bernasconi, S
AU  - Bernasconi S
FAU - Zocchi, M R
AU  - Zocchi MR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Antigens, CD)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Integrin alpha1)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Antigens, CD/chemistry/*physiology
MH  - Carcinoma, Renal Cell/*immunology/pathology
MH  - Cell Movement/immunology
MH  - Chemokine CCL2/biosynthesis
MH  - Endothelium/immunology/pathology
MH  - Extracellular Matrix/immunology
MH  - Humans
MH  - In Vitro Techniques
MH  - Integrin alpha1
MH  - Interleukin-8/biosynthesis
MH  - Kidney Neoplasms/*immunology/pathology
MH  - Lymphocytes, Tumor-Infiltrating/*immunology/pathology
EDAT- 1998/08/26 02:19
MHDA- 2000/06/20 09:00
CRDT- 1998/08/26 02:19
PHST- 1998/08/26 02:19 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1998/08/26 02:19 [entrez]
AID - 10.1002/(SICI)1521-4141(199808)28:08<2530::AID-IMMU2530>3.0.CO;2-6 [pii]
AID - 10.1002/(SICI)1521-4141(199808)28:08<2530::AID-IMMU2530>3.0.CO;2-6 [doi]
PST - ppublish
SO  - Eur J Immunol. 1998 Aug;28(8):2530-6. doi: 
      10.1002/(SICI)1521-4141(199808)28:08<2530::AID-IMMU2530>3.0.CO;2-6.