PMID- 9712199
OWN - NLM
STAT- MEDLINE
DCOM- 19981007
LR  - 20071114
IS  - 1059-910X (Print)
IS  - 1059-910X (Linking)
VI  - 41
IP  - 6
DP  - 1998 Jun 15
TI  - Segregated pathways in the vomeronasal system.
PG  - 519-29
AB  - The vomeronasal system of mammals is chemoarchitecturally dichotomous. Two 
      populations of receptor cells have been identified in the vomeronasal sensory 
      epithelium based on the family of receptor proteins they express on their 
      membranes. These two receptor cell populations express different G-proteins: the 
      more basal population expresses Goalpha and the more apical population expresses 
      Gialpha2. The Goalpha-expressing receptor cells project their axons to the 
      posterior accessory olfactory bulb (AOB) whereas the Gialpha2-expressing cells 
      project their axons to the anterior AOB. In all mammals studied to date, the 
      anterior AOB is Gialpha2-positive and the posterior AOB is Goalpha-positive. 
      These two parts of the AOB are also chemoarchitecturally heterogeneous with 
      respect to their carbohydrate content as revealed both with lectin binding and 
      immunoreactivity to monoclonal antibodies raised against carbohydrate moieties. 
      However, species differences have been observed with respect to lectin binding, 
      as with NADPH-diaphorase reactions and OMP immunoreactivity. Recent studies 
      indicate that there are physiological and behavioral correlates to the dichotomy 
      within the vomeronasal system.
FAU - Halpern, M
AU  - Halpern M
AD  - Department of Anatomy and Cell Biology, SUNY Health Science Center at Brooklyn, 
      New York 11203, USA. MHalpern@Netmail.hscbklyn.edu
FAU - Jia, C
AU  - Jia C
FAU - Shapiro, L S
AU  - Shapiro LS
LA  - eng
GR  - DC02745/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Microsc Res Tech
JT  - Microscopy research and technique
JID - 9203012
RN  - 0 (Glycoconjugates)
RN  - 0 (Lectins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Olfactory Marker Protein)
RN  - 0 (Receptors, Cell Surface)
RN  - EC 1.6.99.1 (NADPH Dehydrogenase)
SB  - IM
MH  - Animals
MH  - Carbohydrate Metabolism
MH  - Glycoconjugates/immunology/metabolism
MH  - Lectins/metabolism
MH  - NADPH Dehydrogenase/metabolism
MH  - Nerve Tissue Proteins/metabolism
MH  - Neurons/metabolism
MH  - Olfactory Bulb/physiology
MH  - Olfactory Marker Protein
MH  - Receptors, Cell Surface/genetics/*metabolism
MH  - Vomeronasal Organ/anatomy & histology/*metabolism
RF  - 66
EDAT- 1998/08/26 02:22
MHDA- 2000/06/22 10:00
CRDT- 1998/08/26 02:22
PHST- 1998/08/26 02:22 [pubmed]
PHST- 2000/06/22 10:00 [medline]
PHST- 1998/08/26 02:22 [entrez]
AID - 10.1002/(SICI)1097-0029(19980615)41:6<519::AID-JEMT7>3.0.CO;2-H [pii]
AID - 10.1002/(SICI)1097-0029(19980615)41:6<519::AID-JEMT7>3.0.CO;2-H [doi]
PST - ppublish
SO  - Microsc Res Tech. 1998 Jun 15;41(6):519-29. doi: 
      10.1002/(SICI)1097-0029(19980615)41:6<519::AID-JEMT7>3.0.CO;2-H.