PMID- 9712364
OWN - NLM
STAT- MEDLINE
DCOM- 19981029
LR  - 20220331
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 18
IP  - 7
DP  - 1998 Jul
TI  - Interferon-alpha response to swine arterivirus (PoAV), the porcine reproductive 
      and respiratory syndrome virus.
PG  - 485-90
AB  - We studied the interferon-alpha (IFN-alpha) system in relation to the porcine 
      arterivirus (PoAV), porcine reproductive and respiratory syndrome virus (PRRSV). 
      Recombinant porcine IFN-alpha inhibited the growth of this virus in alveolar 
      macrophage cultures. When pigs were challenged intranasally with PoAV, their 
      serum contained IFN-alpha in relatively low concentrations on the second day 
      after challenge and up to 5 days at the latest. Most animals had no IFN-alpha in 
      their lung secretions, even though PoAV replicates in the respiratory tract. In 
      vitro, PoAV replicates in alveolar macrophages, but neither these nor peripheral 
      blood mononuclear cells (PBMC) produced IFN-alpha in response to infection. This 
      may be because PoAV suppresses IFN-alpha production. When macrophages treated 
      with PoAV were superinfected with swine transmissible gastroenteritis virus 
      (TGEV), a known good inducer of IFN, no IFN-alpha was detected. This suppressive 
      effect was lost when the virus was inactivated by UV light. Our results suggest 
      that downregulation of IFN-alpha production may play an important part in 
      enabling PoAV to replicate in cell cultures and in pigs.
FAU - Albina, E
AU  - Albina E
AD  - CNEVA-Ploufragan, Unite de Virologie et Immunologie Porcines, France. 
      e.albina@ploufragan.cneva.fr
FAU - Carrat, C
AU  - Carrat C
FAU - Charley, B
AU  - Charley B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Interferon Inducers)
RN  - 0 (Interferon Type I)
RN  - 0 (Interferon-alpha)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Administration, Intranasal
MH  - Animals
MH  - Cells, Cultured
MH  - *Interferon Inducers
MH  - Interferon Type I/*pharmacology
MH  - Interferon-alpha/*biosynthesis
MH  - Leukocytes, Mononuclear/drug effects/metabolism/virology
MH  - Macrophages, Alveolar/drug effects/metabolism/virology
MH  - *Porcine respiratory and reproductive syndrome virus
MH  - Recombinant Proteins
MH  - Swine
MH  - *Virus Replication
EDAT- 1998/08/26 00:00
MHDA- 1998/08/26 00:01
CRDT- 1998/08/26 00:00
PHST- 1998/08/26 00:00 [pubmed]
PHST- 1998/08/26 00:01 [medline]
PHST- 1998/08/26 00:00 [entrez]
AID - 10.1089/jir.1998.18.485 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 1998 Jul;18(7):485-90. doi: 10.1089/jir.1998.18.485.