PMID- 9714720
OWN - NLM
STAT- MEDLINE
DCOM- 19981005
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 216
IP  - 1
DP  - 1998 Aug 17
TI  - The human glucosamine-6-phosphate deaminase gene: cDNA cloning and expression, 
      genomic organization and chromosomal localization.
PG  - 31-8
AB  - When mammalian eggs are fertilized by sperm, a distinct series of calcium 
      oscillations are generated which serve as the essential trigger for egg 
      activation and early embryo development. The identification of a soluble hamster 
      sperm 33-kDa protein that co-migrated with calcium oscillation-inducing activity 
      was recently described by Parrington et al. (Parrington, J., Swann, K., 
      Shevchenko, V.I., Sesay, A.K. and Lai, F.A., 1996. Calcium oscillations in 
      mammalian eggs triggered by a soluble sperm protein. Nature 379, 364-368). The 
      hamster sperm 33 kDa protein was termed oscillin because it correlated with 
      calcium oscillation-inducing activity in mammalian eggs. Sequence analysis of the 
      hamster sperm 33 kDa protein indicated no similarity to any known cell signalling 
      molecule, however, it displayed extensive homology with a bacterial 
      glucosamine-6-phosphate deaminase. We have isolated the corresponding human 
      testis homologue of the hamster sperm 33 kDa cDNA. Nucleotide sequence analysis 
      reveals a high level of sequence identity between the hamster and human genes. 
      The deduced protein sequence of the human gene also shares extensive amino acid 
      identity with the bacterial glucosamine-6-phosphate deaminase enzyme. 
      Heterologous expression of the human testis 33 kDa protein produced a 
      glucosamine-6-phosphate deaminase activity. The genomic structure of the human 
      glucosamine-6-phosphate deaminase has been mapped and the gene was localized by 
      fluorescence in situ hybridization (FISH) to chromosome 5q31.
FAU - Shevchenko, V
AU  - Shevchenko V
AD  - MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.
FAU - Hogben, M
AU  - Hogben M
FAU - Ekong, R
AU  - Ekong R
FAU - Parrington, J
AU  - Parrington J
FAU - Lai, F A
AU  - Lai FA
LA  - eng
SI  - GENBANK/AJ002231
PT  - Journal Article
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (DNA, Complementary)
RN  - EC 3.5.99.6 (glucosamine-6-phosphate isomerase)
RN  - EC 5.3.1.- (Aldose-Ketose Isomerases)
SB  - IM
MH  - Aldose-Ketose Isomerases/chemistry/*genetics
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 5/genetics
MH  - DNA, Complementary/chemistry/genetics
MH  - Escherichia coli/enzymology/genetics
MH  - Exons/genetics
MH  - Gene Expression/genetics
MH  - Genes/*genetics
MH  - Humans
MH  - Introns/genetics
MH  - Male
MH  - Molecular Sequence Data
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Testis/chemistry/metabolism
EDAT- 1998/08/26 00:00
MHDA- 1998/08/26 00:01
CRDT- 1998/08/26 00:00
PHST- 1998/08/26 00:00 [pubmed]
PHST- 1998/08/26 00:01 [medline]
PHST- 1998/08/26 00:00 [entrez]
AID - S0378-1119(98)00335-7 [pii]
AID - 10.1016/s0378-1119(98)00335-7 [doi]
PST - ppublish
SO  - Gene. 1998 Aug 17;216(1):31-8. doi: 10.1016/s0378-1119(98)00335-7.