PMID- 9715805
OWN - NLM
STAT- MEDLINE
DCOM- 19981105
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 61
IP  - 1
DP  - 1998 Sep
TI  - Long-term monoamine depletion, differential recovery, and subtle behavioral 
      impairment following methamphetamine-induced neurotoxicity.
PG  - 35-44
AB  - Squads of rats were assayed at three intervals following MA-induced neurotoxicity 
      to investigate the persistence of monoamine deficits, the potential for monoamine 
      recovery, and spatial task abilities. At 48, 139, and 237 days postinjection, MA 
      animals showed significant monoamine depletions compared with controls. 
      Investigating percent depletions (MA/control) across time showed monoamine 
      recovery in some structures. Initially, 5-HT within medial prefrontal cortex 
      (MPFC), caudate (CdN), and hippocampus (HPC) was reduced to 30% of control 
      levels. By 237 days, MPFC and CdN levels were elevated to 70%. Similarly, initial 
      CdN DA reductions (30% of control levels) showed recovery to 80% by 237 days. 
      These findings support neurochemical recovery following MA neurotoxicity. 
      However, the persistent depression of HPC 5-HT suggests that not all structures 
      recover equally. The HPC did show elevated turnover (metabolite/neurotransmitter) 
      over time, suggesting a unique compensatory response. MA treatment also produced 
      an impairment in the Morris water-maze place task at 65 days postinjection. No 
      impairments were observed in water-maze moving platform or place task at 79 and 
      165 days postinjection, respectively, or in T-maze alternation. The possibility 
      that partial recovery in tissue monamine levels underlies the sparing of function 
      and behavioral improvement is discussed.
FAU - Friedman, S D
AU  - Friedman SD
AD  - University of New Mexico, Department of Psychology, Albuquerque, USA.
FAU - Castaneda, E
AU  - Castaneda E
FAU - Hodge, G K
AU  - Hodge GK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Central Nervous System Stimulants)
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Biogenic Monoamines/*metabolism
MH  - Central Nervous System Stimulants/*toxicity
MH  - Male
MH  - Maze Learning/drug effects
MH  - Methamphetamine/*toxicity
MH  - Nervous System Diseases/chemically induced/*metabolism/*psychology
MH  - Orientation/drug effects
MH  - Psychomotor Performance/drug effects
MH  - Rats
EDAT- 1998/08/26 00:00
MHDA- 1998/08/26 00:01
CRDT- 1998/08/26 00:00
PHST- 1998/08/26 00:00 [pubmed]
PHST- 1998/08/26 00:01 [medline]
PHST- 1998/08/26 00:00 [entrez]
AID - S0091-3057(98)00066-5 [pii]
AID - 10.1016/s0091-3057(98)00066-5 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1998 Sep;61(1):35-44. doi: 
      10.1016/s0091-3057(98)00066-5.