PMID- 9715951
OWN - NLM
STAT- MEDLINE
DCOM- 19980902
LR  - 20190516
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 59
IP  - 2
DP  - 1998 Aug
TI  - HLA-DP control of human Schistosoma haematobium infection.
PG  - 302-6
AB  - The DPA1 and DPB1 alleles of the major histocompatibility complex (MHC) class II 
      were determined in 110 patients and 120 healthy controls of a Gabonese population 
      from an area endemic for Schistosoma haematobium infection. The MHC-DP alleles of 
      the variable second exons and their human leukocyte antigen (HLA) epitopes were 
      correlated with egg excretion, interleukin-4 and interferon-gamma patterns, and 
      bladder abnormalities, as detected by ultrasonography. A methionine at position 
      11 of the DP alpha molecule (Met-11) and DPA1*0301 were associated with 
      schistosomiasis when compared with controls (phenotypic gene frequencies = 0.791 
      versus 0.583 and 0.555 versus 0.375, respectively). Met-11 homozygosity occurred 
      more often in patients, whereas healthy controls were more frequently homozygous 
      for an alanine at position 11 (Ala-11). The combination of the DPB1-epitope DEAV 
      (positions 84-87 of the DP beta molecule) and Met-11 positive DPA1 alleles was 
      more frequent in patients than in controls (0.573 versus 0.316). Two years after 
      antischistosomal treatment, the rate of reinfection as examined in 55 of the 110 
      former patients was higher in DPA1*0301-positive individuals than in those not 
      possessing this allele (P < 0.001). Ala-11 positive individuals showed less 
      frequently ultrasonographic signs of bladder pathology than Ala-11 negative 
      individuals (P < 0.05). Our results suggest a role of MHC-DP elements in the 
      manifestation of disease in S. haematobium infection.
FAU - May, J
AU  - May J
AD  - Institut fur Tropenmedizin und Medizinische Fakultat der Charite, 
      Humboldt-Universitat zu Berlin, Germany.
FAU - Kremsner, P G
AU  - Kremsner PG
FAU - Milovanovic, D
AU  - Milovanovic D
FAU - Schnittger, L
AU  - Schnittger L
FAU - Loliger, C C
AU  - Loliger CC
FAU - Bienzle, U
AU  - Bienzle U
FAU - Meyer, C G
AU  - Meyer CG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (HLA-DP Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Child
MH  - Disease Susceptibility
MH  - Gene Frequency
MH  - HLA-DP Antigens/*genetics/immunology
MH  - Humans
MH  - Phenotype
MH  - Recurrence
MH  - Schistosomiasis haematobia/genetics/*immunology/pathology
MH  - Ultrasonography
MH  - Urinary Bladder/diagnostic imaging/*pathology
EDAT- 1998/08/26 00:00
MHDA- 1998/08/26 00:01
CRDT- 1998/08/26 00:00
PHST- 1998/08/26 00:00 [pubmed]
PHST- 1998/08/26 00:01 [medline]
PHST- 1998/08/26 00:00 [entrez]
AID - 10.4269/ajtmh.1998.59.302 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 1998 Aug;59(2):302-6. doi: 10.4269/ajtmh.1998.59.302.