PMID- 9717443
OWN - NLM
STAT- MEDLINE
DCOM- 19980918
LR  - 20131121
IS  - 0019-5189 (Print)
IS  - 0019-5189 (Linking)
VI  - 36
IP  - 4
DP  - 1998 Apr
TI  - Immunoreactive riboflavin carrier protein concentration during ovulatory cycle in 
      the common marmoset (Callithrix jachhus): role of estrogen.
PG  - 353-7
AB  - Common marmoset, a non-human primate, is increasingly being used as a model 
      system in reproductive endocrinology. Marmosets do not menstruate but have normal 
      cycle length of 28 +/- 2 days. The presence of protein immunologically and 
      functionally similar to the well characterized chicken riboflavin carrier protein 
      (cRCP) has been demonstrated in circulation in pregnant marmosets. Marmoset RCP 
      (mRCP) has been partially purified and the molecular weight of the immunoreactive 
      protein is similar to cRCP. The source of RCP in rodents appears to be maternal 
      liver, suggesting thereby that RCP levels could be modulated by changing hormonal 
      pattern that occurs during the cycle. To study the hormonal control of marmoset 
      RCP, immunoreactive RCP levels were monitored during normal cycle. Plasma 
      progesterone was estimated by RIA and mRCP was measured using a heterologous cRCP 
      RIA. When mRCP and progesterone were analysed for a period of 40 days (n = 5) in 
      adult females, very low amount of mRCP was measured during the luteal phase and a 
      single sharp peak was observed during the follicular phase of the cycle. These 
      data suggested that the induction of mRCP was regulated by estrogen. Direct 
      evidence for the role of estrogen in the elaboration of RCP, was the observation 
      that exogenous administration of estradiol 17 B to immature marmosets resulted in 
      a time and dose dependent increase in plasma RCP levels. As early as 24 hr 
      following hormonal administration, a measurable increase in mRCP with a maximum 
      increase, 5-fold over the zero period was seen 3 days following a single 
      administration of estradiol 17 B (5 mg/kg body wt). RCP levels declined 
      thereafter and was indistinguishable by day 7. These studies indicate that the 
      marmoset RCP levels are regulated by estrogen.
FAU - Natraj, U
AU  - Natraj U
AD  - Institute for Research in Reproduction (ICMR), Parel, Bombay, India.
FAU - Pereira, J
AU  - Pereira J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian J Exp Biol
JT  - Indian journal of experimental biology
JID - 0233411
RN  - 0 (Carrier Proteins)
RN  - 0 (Estrogens)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (riboflavin-binding protein)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - TLM2976OFR (Riboflavin)
SB  - IM
MH  - Animals
MH  - Callithrix
MH  - Carrier Proteins/*blood/metabolism
MH  - Estrogens/*physiology
MH  - Female
MH  - *Membrane Transport Proteins
MH  - Ovulation/*physiology
MH  - Pregnancy
MH  - Progesterone/blood
MH  - Radioimmunoassay
MH  - Riboflavin/*metabolism
EDAT- 1998/08/26 00:00
MHDA- 1998/08/26 00:01
CRDT- 1998/08/26 00:00
PHST- 1998/08/26 00:00 [pubmed]
PHST- 1998/08/26 00:01 [medline]
PHST- 1998/08/26 00:00 [entrez]
PST - ppublish
SO  - Indian J Exp Biol. 1998 Apr;36(4):353-7.