PMID- 9718134
OWN - NLM
STAT- MEDLINE
DCOM- 19981103
LR  - 20191102
IS  - 1355-0284 (Print)
IS  - 1355-0284 (Linking)
VI  - 4
IP  - 4
DP  - 1998 Aug
TI  - Tissue specific distribution of the herpes simplex virus type 1 
      latency-associated transcripts on polyribosomes during latent infection.
PG  - 426-32
AB  - Transcription of herpes simplex virus type 1 (HSV-1) during latency produces two 
      abundant latency-associated transcripts (LATs). We have recently shown, that 
      during HSV-1 latency in mice trigeminal ganglia (TG) LATs are bound to 
      polyribosomes (J Virol, 1997, 71, 2897-2904). In order to study the possible role 
      of this binding in the latency process, we now extend the polyribosomal analysis 
      to brainstem tissues of latently infected mice, that unlike TG do not support 
      viral reactivation. We report here that the relative amounts of the LATs 
      associated with polyribosomes in the brainstems of mice are significantly lower 
      than those present in TG. We therefore show that binding of the 1.5 and 2.0 
      kilobases LATs to polyribosomes is tissue specific and hypothesize that this 
      association may have a role in the reactivation function of HSV-1.
FAU - Goldenberg, D
AU  - Goldenberg D
AD  - Department of Neurology, Hadassah University Hospital, Jerusalem, Israel.
FAU - Mador, N
AU  - Mador N
FAU - Panet, A
AU  - Panet A
FAU - Steiner, I
AU  - Steiner I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (RNA, Ribosomal)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - Brain Stem/virology
MH  - Carrier State
MH  - Female
MH  - Gene Expression Regulation, Viral
MH  - Herpes Simplex/*virology
MH  - Herpesvirus 1, Human/*genetics
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Polyribosomes/*virology
MH  - RNA, Ribosomal/analysis
MH  - RNA, Viral/analysis
MH  - Transcription, Genetic/*physiology
MH  - Trigeminal Nerve/virology
EDAT- 1998/08/26 00:00
MHDA- 1998/08/26 00:01
CRDT- 1998/08/26 00:00
PHST- 1998/08/26 00:00 [pubmed]
PHST- 1998/08/26 00:01 [medline]
PHST- 1998/08/26 00:00 [entrez]
AID - 10.3109/13550289809114541 [doi]
PST - ppublish
SO  - J Neurovirol. 1998 Aug;4(4):426-32. doi: 10.3109/13550289809114541.