PMID- 971958
OWN - NLM
STAT- MEDLINE
DCOM- 19761203
LR  - 20210526
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 14
IP  - 2
DP  - 1976 Aug
TI  - Inherited resistance to Corynebacterium kutscheri in mice.
PG  - 475-82
AB  - An analysis of the factors responsible for inherited resistance to 
      Corynebacterium kutscheri was undertaken. Various inbred mouse strains were 
      examined; these included the Swiss Lynch and C57Bl/l mice, their F1 and F2 
      progeny, and the progeny of the F1 backcrossed to each parent strain. Two modes 
      of inherited resistance are described. An examination suggested that resistance 
      as measured by the mean lethal dose of C. kutscheri was under polygenic control 
      and was inherited continuously. However, the efficiency with which C. kutscheri 
      was eliminated by the mononuclear phagocyte cells of the liver over 3 days 
      differed markedly among strains. A genetic analysis of this mononuclear phagocyte 
      microbicidal efficiency (MPME) in Swiss Lynch and C57Bl/6 mice was undertaken. 
      The trait, MPME, was present, but did not segregate, in the F1 progeny or in the 
      progeny of the backcross to the resistant C57Bl/6 parent; this was clear evidence 
      of dominance. Moreover, MPME segregated in a ratio of 1:1 in the progeny of the 
      backcross to the sensitive Swiss Lynch parent and in a ratio of 3:1 in the F2 
      progeny. It was concluded that MPME was inherited discontinuously and was 
      controlled by a single dominant autosomal gene (or closely linked group); the 
      recessive allele was assigned the gene symbol ack. Linkage experiments showed 
      there to be no association between the ack locus and any of the immune-response 
      genes.
FAU - Hirst, R G
AU  - Hirst RG
FAU - Wallace, M E
AU  - Wallace ME
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
SB  - IM
MH  - Animals
MH  - Breeding
MH  - Chromosome Mapping
MH  - Corynebacterium/*pathogenicity
MH  - Corynebacterium Infections/*genetics
MH  - Genes, Dominant
MH  - Lethal Dose 50
MH  - Mice
MH  - Mice, Inbred A
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred CBA
MH  - Mice, Inbred DBA
MH  - Phagocytes/microbiology
PMC - PMC420909
EDAT- 1976/08/01 00:00
MHDA- 1976/08/01 00:01
PMCR- 1976/08/01
CRDT- 1976/08/01 00:00
PHST- 1976/08/01 00:00 [pubmed]
PHST- 1976/08/01 00:01 [medline]
PHST- 1976/08/01 00:00 [entrez]
PHST- 1976/08/01 00:00 [pmc-release]
AID - 10.1128/iai.14.2.475-482.1976 [doi]
PST - ppublish
SO  - Infect Immun. 1976 Aug;14(2):475-82. doi: 10.1128/iai.14.2.475-482.1976.