PMID- 9720182
OWN - NLM
STAT- MEDLINE
DCOM- 19980924
LR  - 20211203
IS  - 0268-9146 (Print)
IS  - 0268-9146 (Linking)
VI  - 29
IP  - 3
DP  - 1998 Jun
TI  - RXRA and HSPA5 map to the telomeric end of dog chromosome 9.
PG  - 220-3
AB  - Previous results showed that loci from human chromosome 17q (HSA17q) map to the 
      centromeric two-thirds of dog chromosome 9 (CFA9). In these studies fluorescence 
      in situ hybridization (FISH) using a human total chromosome 17 painting probe, 
      indicated that the telomeric one-third of CFA9 must have homology to one or more 
      human chromosomes other than HSA17. Here we report that this distal part of CFA9 
      contains a segment syntenic to the telomeric end of HSA9q and mouse chromosome 2 
      (MMU2). The gene loci encoding retinoid X receptor, alpha (RXRA) and heat shock 
      protein 5 (HSPA5 or GRP78), which are found on HSA9q34 and MMU2, occupy a region 
      on CFA9 distal to NF1 and CRYBA1. FISH of a canine specific genomic cosmid clone 
      for RXRA demonstrated the more telomeric localization of this locus to NF1 on 
      CFA9. A linkage map developed for the distal region of CFA9 included: NF1-(2.7 
      CM)-CRYBA1-(6.5 CM)-RXRA-(22CM)-HSPA5. The next best order, RXRA-NF1-CRYBA1-HSPA5 
      with a difference in the log odds of 1.43 does not correspond to our findings 
      with FISH. The most probable map order places HSPA5 distal to RXRA on CFA9 
      whereas in humans it lies centromeric of RXRA on HSA9q34.
FAU - Werner, P
AU  - Werner P
AD  - Center for Comparative Medical Genetics, School of Veterinary Medicine, 
      University of Pennsylvania, Philadelphia 19104-6010, USA.
FAU - Raducha, M G
AU  - Raducha MG
FAU - Prociuk, U
AU  - Prociuk U
FAU - Lyons, L A
AU  - Lyons LA
FAU - Kehler, J S
AU  - Kehler JS
FAU - Henthorn, P S
AU  - Henthorn PS
FAU - Patterson, D F
AU  - Patterson DF
LA  - eng
GR  - HL18848/HL/NHLBI NIH HHS/United States
GR  - RR02512/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Anim Genet
JT  - Animal genetics
JID - 8605704
RN  - 0 (Carrier Proteins)
RN  - 0 (Endoplasmic Reticulum Chaperone BiP)
RN  - 0 (Genetic Markers)
RN  - 0 (HSPA5 protein, human)
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (Hspa5 protein, mouse)
RN  - 0 (Molecular Chaperones)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Carrier Proteins/*genetics
MH  - *Chromosome Mapping
MH  - Chromosomes, Human, Pair 17
MH  - Dogs/*genetics
MH  - Endoplasmic Reticulum Chaperone BiP
MH  - Genetic Linkage
MH  - Genetic Markers
MH  - *Heat-Shock Proteins
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lod Score
MH  - Mice
MH  - Molecular Chaperones/*genetics
MH  - Polymerase Chain Reaction
MH  - Receptors, Retinoic Acid/*genetics
MH  - Retinoid X Receptors
MH  - Telomere/*genetics
MH  - Transcription Factors/*genetics
EDAT- 1998/08/28 00:00
MHDA- 1998/08/28 00:01
CRDT- 1998/08/28 00:00
PHST- 1998/08/28 00:00 [pubmed]
PHST- 1998/08/28 00:01 [medline]
PHST- 1998/08/28 00:00 [entrez]
AID - 10.1046/j.1365-2052.1998.00328.x [doi]
PST - ppublish
SO  - Anim Genet. 1998 Jun;29(3):220-3. doi: 10.1046/j.1365-2052.1998.00328.x.