PMID- 9720277
OWN - NLM
STAT- MEDLINE
DCOM- 19981002
LR  - 20091119
IS  - 0016-6707 (Print)
IS  - 0016-6707 (Linking)
VI  - 102-103
IP  - 1-6
DP  - 1998
TI  - Selection, convergence, and intragenic recombination in HLA diversity.
PG  - 157-69
AB  - To account for high degrees of human leukocyte antigen (HLA) diversity, a method 
      is proposed for detecting intragenic recombination or gene conversion separately 
      from parallel substitutions or convergent evolution. An application of the method 
      to HLA protein sequences suggests that intragenic recombination played important 
      roles in HLA-B and DPB1, some in HLA-A and DRB1, and least in HLA-C and DQB1 
      diversity. However, the extent of diversity of these molecules does not 
      necessarily correlate with the frequency of intragenic recombination, supporting 
      the view that (balancing) selection is a primary agent of HLA diversity and often 
      leads to convergent evolution. Computer simulation is carried out to examine two 
      models of balancing selection under the coupled effect with mutation, intragenic 
      recombination, and random drift in a diploid population. It is emphasized that 
      break points by intragenic recombination need be specified to account for HLA 
      diversity. Implications of HLA diversity in human evolution are briefly 
      discussed.
FAU - Takahata, N
AU  - Takahata N
AD  - Department of Biosystems Science, Graduate University for Advanced Studies, 
      Kanagawa, Japan. takahata@soken.ac.jp
FAU - Satta, Y
AU  - Satta Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Genetica
JT  - Genetica
JID - 0370740
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Amino Acid Sequence
MH  - Computer Simulation
MH  - *Evolution, Molecular
MH  - Gene Conversion
MH  - *Genetic Variation
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/chemistry/genetics
MH  - HLA-B Antigens/chemistry/genetics
MH  - HLA-C Antigens/chemistry/genetics
MH  - Humans
MH  - *Models, Genetic
MH  - Models, Statistical
MH  - *Recombination, Genetic
MH  - *Selection, Genetic
EDAT- 1998/08/28 00:00
MHDA- 1998/08/28 00:01
CRDT- 1998/08/28 00:00
PHST- 1998/08/28 00:00 [pubmed]
PHST- 1998/08/28 00:01 [medline]
PHST- 1998/08/28 00:00 [entrez]
PST - ppublish
SO  - Genetica. 1998;102-103(1-6):157-69.