PMID- 9720822
OWN - NLM
STAT- MEDLINE
DCOM- 19981110
LR  - 20190831
IS  - 0954-7894 (Print)
IS  - 0954-7894 (Linking)
VI  - 28
IP  - 7
DP  - 1998 Jul
TI  - Exhaled and nasal nitric oxide is increased in laboratory animal allergy.
PG  - 876-80
AB  - BACKGROUND: Allergens from rats, mice, guinea pigs or rabbits cause up to 30% of 
      exposed persons to develop specific immunoglobulin E (IgE) responses. Laboratory 
      animal allergy (LAA) is among the highest occupational risks for asthma in the 
      UK. Elevated levels of nitric oxide (NO) are found in exhaled breath in asthma. 
      In LAA symptoms may progress from conjunctivitis, rhinitis to asthma. Health 
      surveillance aims to detect early sensitization. OBJECTIVE: To assess whether an 
      association exists between LAA and exhaled NO. METHODS: A cross-sectional study 
      was performed in 39 laboratory workers undergoing LAA health surveillance. 
      Volunteers completed two health questionnaires, had skin-prick tests, spirometry, 
      total IgE and RAST tests. Exhaled and nasal NO was measured by chemiluminescence 
      analyser (LR2000, Logan Research, Rochester, UK). RESULTS: There were 23 
      asymptomatic subjects (mean age 29.53 years) and 16 symptomatic subjects (29.63 
      years, P=0.95); 9 early LAA, seven LAA asthma. Exhaled NO was raised in those 
      with LAA symptoms 17.97 ppb+/-1.24 (mean+/-SEM) compared with asymptomatics 6.08 
      ppb+/-1.15, P < 0.05. A trend of increased NO by allergic status was observed; 
      asymptomatic, to early LAA, to asthma. One-way analysis of variance compared 
      differences between groups (F ratio 13.93, P < 0.001). Symptomatic subjects also 
      had raised nasal NO, vs asymptomatic subjects (mean difference 378 ppb, P < 
      0.05). A trend was again observed by allergic status (F ratio 5.28, P=0.01). 
      CONCLUSION: Raised NO levels in LAA increasing with symptom severity suggest NO 
      may prove a useful additional tool in monitoring for LAA, and possibly the 
      response to exposure reduction or allergy due to other respiratory sensitizers.
FAU - Adisesh, L A
AU  - Adisesh LA
AD  - Occupational Health Department of United Medical and Dental Schools of Guy's & St 
      Thomas' Hospitals, London, UK.
FAU - Kharitonov, S A
AU  - Kharitonov SA
FAU - Yates, D H
AU  - Yates DH
FAU - Snashell, D C
AU  - Snashell DC
FAU - Newman-Taylor, A J
AU  - Newman-Taylor AJ
FAU - Barnes, P J
AU  - Barnes PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Animals
MH  - *Animals, Laboratory
MH  - Female
MH  - Humans
MH  - Hypersensitivity/diagnosis/immunology/*physiopathology
MH  - Immunoglobulin E/blood
MH  - Luminescent Measurements
MH  - Male
MH  - Mice
MH  - Nitric Oxide/*analysis
MH  - Occupational Diseases/diagnosis/immunology/*physiopathology
MH  - Rabbits
MH  - Radioallergosorbent Test
MH  - Rats
MH  - Respiration
MH  - Skin Tests
MH  - Spirometry
MH  - Surveys and Questionnaires
EDAT- 1998/08/28 00:00
MHDA- 1998/08/28 00:01
CRDT- 1998/08/28 00:00
PHST- 1998/08/28 00:00 [pubmed]
PHST- 1998/08/28 00:01 [medline]
PHST- 1998/08/28 00:00 [entrez]
AID - 10.1046/j.1365-2222.1998.00332.x [doi]
PST - ppublish
SO  - Clin Exp Allergy. 1998 Jul;28(7):876-80. doi: 10.1046/j.1365-2222.1998.00332.x.