PMID- 9722189
OWN - NLM
STAT- MEDLINE
DCOM- 19981120
LR  - 20190909
IS  - 0165-1838 (Print)
IS  - 0165-1838 (Linking)
VI  - 71
IP  - 1
DP  - 1998 Jun 30
TI  - Centrally administered TRH-induced insulin secretion is impaired in the 
      Otsuka-Long-Evans-Tokushima Fatty rats, a model of spontaneous 
      non-insulin-dependent diabetes mellitus.
PG  - 10-7
AB  - To investigate whether insulin secretion induced by stimulation of the vagus 
      nerve is preserved or impaired in Otsuka-Long-Evans-Tokushima Fatty (OLETF) rats, 
      we injected 10(-8) mol of thyrotropin-releasing hormone (TRH) into the third 
      cerebral ventricle and determined the serum level of insulin in the 
      unanesthetized, unrestrained rats. Intracerebroventricular (i.c.v.) injection 
      increased the serum levels of glucose and insulin in both OLETF and 
      Long-Evans-Tokushima-Otsuka (LETO) rats, a nondiabetic control strain, at 8-12 
      weeks of age. At 24-28 weeks of age, the increased level of glucose in OLETF rats 
      was comparable to LETO rats but that of insulin was lower than control after the 
      i.c.v. injection of TRH. Pretreatment with i.v. atropine had no significant 
      effect on such hyperglycemia. However, the increases in the serum levels of 
      insulin were suppressed in both OLETF and LETO rats. The plasma levels of 
      epinephrine, norepinephrine, and glucagon rose significantly after TRH. There was 
      no significant difference in the levels of any hormones between the two groups. 
      In OLETF rats at 24-28 weeks of age, i.v. glucose load induced significantly 
      higher serum levels of glucose and insulin than LETO rats. The results suggest 
      that the vagus nerve-mediated insulin secretion is impaired in OLETF rats, 
      similar to an autonomic diabetic neuropathy in the early stage of diabetes. This 
      impairment may play some role in deteriorating glucose tolerance in this 
      spontaneously developed diabetes model.
FAU - Chen, Y
AU  - Chen Y
AD  - Department of Geriatric Medicine, Nagoya University School of Medicine, Japan.
FAU - Uemura, K
AU  - Uemura K
FAU - Yoshioka, S
AU  - Yoshioka S
FAU - Surina-Baumgartner, D M
AU  - Surina-Baumgartner DM
FAU - Miura, H
AU  - Miura H
FAU - Tamagawa, T
AU  - Tamagawa T
FAU - Hotta, N
AU  - Hotta N
FAU - Iguchi, A
AU  - Iguchi A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Auton Nerv Syst
JT  - Journal of the autonomic nervous system
JID - 8003419
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Parasympatholytics)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - 7C0697DR9I (Atropine)
SB  - IM
MH  - Animals
MH  - Atropine/pharmacology
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus/*metabolism/physiopathology
MH  - Diabetes Mellitus, Type 2/*metabolism/physiopathology
MH  - Glucose Tolerance Test
MH  - Hyperglycemia/blood/chemically induced
MH  - Injections, Intraventricular
MH  - Insulin/blood/*metabolism
MH  - Insulin Secretion
MH  - Male
MH  - *Obesity
MH  - Parasympatholytics/pharmacology
MH  - Rats
MH  - Rats, Inbred OLETF
MH  - Rats, Inbred Strains
MH  - Reference Values
MH  - Thyrotropin-Releasing Hormone/*administration & dosage/pharmacology
MH  - Vagus Nerve/physiopathology
EDAT- 1998/08/29 00:00
MHDA- 1998/08/29 00:01
CRDT- 1998/08/29 00:00
PHST- 1998/08/29 00:00 [pubmed]
PHST- 1998/08/29 00:01 [medline]
PHST- 1998/08/29 00:00 [entrez]
AID - S0165183898000551 [pii]
AID - 10.1016/s0165-1838(98)00055-1 [doi]
PST - ppublish
SO  - J Auton Nerv Syst. 1998 Jun 30;71(1):10-7. doi: 10.1016/s0165-1838(98)00055-1.