PMID- 9722620
OWN - NLM
STAT- MEDLINE
DCOM- 19980925
LR  - 20240326
IS  - 0021-9525 (Print)
IS  - 1540-8140 (Electronic)
IS  - 0021-9525 (Linking)
VI  - 142
IP  - 4
DP  - 1998 Aug 24
TI  - Functional gap junctions in the schwann cell myelin sheath.
PG  - 1095-104
AB  - The Schwann cell myelin sheath is a multilamellar structure with distinct 
      structural domains in which different proteins are localized. Intracellular dye 
      injection and video microscopy were used to show that functional gap junctions 
      are present within the myelin sheath that allow small molecules to diffuse 
      between the adaxonal and perinuclear Schwann cell cytoplasm. Gap junctions are 
      localized to periodic interruptions in the compact myelin called 
      Schmidt-Lanterman incisures and to paranodes; these regions contain at least one 
      gap junction protein, connexin32 (Cx32). The radial diffusion of low molecular 
      weight dyes across the myelin sheath was not interrupted in myelinating Schwann 
      cells from cx32-null mice, indicating that other connexins participate in forming 
      gap junctions in these cells. Owing to the unique geometry of myelinating Schwann 
      cells, a gap junction-mediated radial pathway may be essential for rapid 
      diffusion between the adaxonal and perinuclear cytoplasm, since this radial 
      pathway is approximately one million times faster than the circumferential 
      pathway.
FAU - Balice-Gordon, R J
AU  - Balice-Gordon RJ
AD  - Department of Neuroscience, The University of Pennsylvania School of Medicine, 
      Philadelphia, Pennsylvania 19104-6074, USA. rbaliceg@mail.med.upenn.edu
FAU - Bone, L J
AU  - Bone LJ
FAU - Scherer, S S
AU  - Scherer SS
LA  - eng
GR  - NS-08075/NS/NINDS NIH HHS/United States
GR  - NS-34373/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (Cadherins)
RN  - 0 (Connexins)
RN  - 0 (Fluoresceins)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Octanols)
RN  - 0 (neurobiotin)
RN  - 6SO6U10H04 (Biotin)
RN  - P540XA09DR (Glycyrrhetinic Acid)
RN  - UQT9G45D1P (Halothane)
SB  - IM
MH  - Animals
MH  - Biotin/analogs & derivatives/metabolism
MH  - Cadherins/analysis
MH  - Connexins/metabolism
MH  - Diffusion
MH  - Fluoresceins/metabolism
MH  - Fluorescent Dyes/metabolism
MH  - Gap Junctions/*physiology
MH  - Glycyrrhetinic Acid/pharmacology
MH  - Halothane/pharmacology
MH  - Mice
MH  - Mice, Knockout
MH  - Microinjections
MH  - Microscopy, Video
MH  - Myelin Sheath/*chemistry
MH  - Octanols/pharmacology
MH  - Schwann Cells/*cytology
MH  - Sciatic Nerve
MH  - Gap Junction beta-1 Protein
PMC - PMC2132877
EDAT- 1998/08/29 00:00
MHDA- 1998/08/29 00:01
PMCR- 1999/02/24
CRDT- 1998/08/29 00:00
PHST- 1998/08/29 00:00 [pubmed]
PHST- 1998/08/29 00:01 [medline]
PHST- 1998/08/29 00:00 [entrez]
PHST- 1999/02/24 00:00 [pmc-release]
AID - 10.1083/jcb.142.4.1095 [doi]
PST - ppublish
SO  - J Cell Biol. 1998 Aug 24;142(4):1095-104. doi: 10.1083/jcb.142.4.1095.