PMID- 9722883
OWN - NLM
STAT- MEDLINE
DCOM- 19980914
LR  - 20190815
IS  - 0304-8608 (Print)
IS  - 0304-8608 (Linking)
VI  - 143
IP  - 7
DP  - 1998
TI  - Experimental infection of pigs with the newly identified swine hepatitis E virus 
      (swine HEV), but not with human strains of HEV.
PG  - 1405-15
AB  - A novel virus of pigs, swine hepatitis E virus (swine HEV), was recently 
      identified and shown to be antigenically and genetically related to human HEV. In 
      the present study, we attempted to infect specific-pathogen-free (SPF) pigs 
      experimentally with swine HEV or with human strains of HEV. Serum samples 
      collected from naturally infected pigs were used as the source of swine HEV. Pigs 
      inoculated intravenously with serum samples containing swine HEV seroconverted to 
      anti-HEV 4 to 8 weeks postinoculation, and the virus spread to an uninoculated 
      pig. Swine HEV was detected in nasal and rectal swab materials as early as 2 
      weeks postinoculation and for 4 to 8 weeks thereafter. Viremia appeared 4 to 6 
      weeks postinoculation and lasted 1 to 3 weeks. The inoculated pigs appeared 
      clinically normal and serum liver enzymes were not significantly elevated. In 
      contrast, pigs were not infected when inoculated intravenously with about 10(5) 
      monkey infectious doses of one of two human strains of HEV (Sar-55 or Mex-14).
FAU - Meng, X J
AU  - Meng XJ
AD  - Hepatitis Viruses Section, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Bethesda, Maryland, USA.
FAU - Halbur, P G
AU  - Halbur PG
FAU - Haynes, J S
AU  - Haynes JS
FAU - Tsareva, T S
AU  - Tsareva TS
FAU - Bruna, J D
AU  - Bruna JD
FAU - Royer, R L
AU  - Royer RL
FAU - Purcell, R H
AU  - Purcell RH
FAU - Emerson, S U
AU  - Emerson SU
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Austria
TA  - Arch Virol
JT  - Archives of virology
JID - 7506870
RN  - 0 (DNA Primers)
RN  - 0 (Hepatitis Antibodies)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - DNA Primers/genetics
MH  - Hepatitis Antibodies/blood
MH  - Hepatitis E/immunology/*veterinary/virology
MH  - Hepatitis E virus/genetics/immunology/*pathogenicity
MH  - Hepatitis, Viral, Animal/immunology/*virology
MH  - Humans
MH  - RNA, Viral/genetics/isolation & purification
MH  - Species Specificity
MH  - Swine
MH  - Swine Diseases/immunology/*virology
EDAT- 1998/09/02 00:00
MHDA- 1998/09/02 00:01
CRDT- 1998/09/02 00:00
PHST- 1998/09/02 00:00 [pubmed]
PHST- 1998/09/02 00:01 [medline]
PHST- 1998/09/02 00:00 [entrez]
AID - 10.1007/s007050050384 [doi]
PST - ppublish
SO  - Arch Virol. 1998;143(7):1405-15. doi: 10.1007/s007050050384.