PMID- 9723025
OWN - NLM
STAT- MEDLINE
DCOM- 19980914
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 105
IP  - 2
DP  - 1998 Sep
TI  - Ring chromosome 4 as the sole cytogenetic anomaly in a chondroblastoma: a case 
      report and review of the literature.
PG  - 109-12
AB  - Chromosome analysis of a chondroblastoma of the right distal femur in a 
      31-year-old male patient revealed a ring chromosome 4 in approximately one-third 
      of the analyzed cells. The remaining cells had a normal karyotype. These findings 
      were subsequently confirmed by fluorescence in situ hybridization (FISH) with a 
      chromosome-4-specific library. FISH with cosmids pC847.351 (4p16.3) and cT171 
      (4q35) revealed that fewer than 300 kilobase pairs (kbp) are deleted. To our 
      knowledge, ring chromosome 4 has never been reported in this type of neoplasm. 
      There are, however, several reports of chondroblastoma with other chromosome 
      abnormalities, but the relation of these anomalies to this tumor specifically is 
      unclear. In this report, we also provide a review of the literature concerning 
      cytogenetic studies in chondroblastoma. The possible significance of ring 
      chromosome 4 in this type of tumor is discussed.
FAU - van Zelderen-Bhola, S L
AU  - van Zelderen-Bhola SL
AD  - Department of Clinical Cytogenetics, Leiden University Medical Center, The 
      Netherlands.
FAU - Bovee, J V
AU  - Bovee JV
FAU - Wessels, H W
AU  - Wessels HW
FAU - Mollevanger, P
AU  - Mollevanger P
FAU - Nijhuis, J V
AU  - Nijhuis JV
FAU - van Eendenburg, J D
AU  - van Eendenburg JD
FAU - Taminiau, A H
AU  - Taminiau AH
FAU - Hogendoorn, P C
AU  - Hogendoorn PC
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Chondroblastoma/*genetics/pathology/therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - *Ring Chromosomes
RF  - 23
EDAT- 1998/09/02 00:00
MHDA- 1998/09/02 00:01
CRDT- 1998/09/02 00:00
PHST- 1998/09/02 00:00 [pubmed]
PHST- 1998/09/02 00:01 [medline]
PHST- 1998/09/02 00:00 [entrez]
AID - S0165460898000168 [pii]
AID - 10.1016/s0165-4608(98)00016-8 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1998 Sep;105(2):109-12. doi: 
      10.1016/s0165-4608(98)00016-8.