PMID- 9724078
OWN - NLM
STAT- MEDLINE
DCOM- 19980911
LR  - 20190905
IS  - 0804-4643 (Print)
IS  - 0804-4643 (Linking)
VI  - 139
IP  - 2
DP  - 1998 Aug
TI  - Comparative genomic hybridization studies in tumours from a patient with multiple 
      endocrine neoplasia type 1.
PG  - 202-6
AB  - OBJECTIVE: To identify genetic changes, other than the MEN1 gene, that might be 
      involved in the tumorigenesis and progression of multiple endocrine neoplasia 
      type 1 (MEN1)-related tumours. METHODS: We used comparative genomic hybridization 
      (CGH) and loss of heterozygosity (LOH) to study tumours from various sites in a 
      patient with MEN1. RESULTS: Gain of genetic material was not found. Frequent 
      losses of genetic material were found in chromosomes 1, 4, 5, 6, 9, 11 and 18. 
      Besides the chromosome 11 where the MEN1 gene is located, the other regions are 
      known to harbour important tumour suppressor genes. CONCLUSIONS: These results 
      suggest the involvement of other cancer-related genes in the tumorigenesis and 
      progression of MEN1 tumours that warrant further investigations.
FAU - Kytola, S
AU  - Kytola S
AD  - Department of Clinical Genetics, Oulu University Hospital, Finland.
FAU - Makinen, M J
AU  - Makinen MJ
FAU - Kahkonen, M
AU  - Kahkonen M
FAU - Teh, B T
AU  - Teh BT
FAU - Leisti, J
AU  - Leisti J
FAU - Salmela, P
AU  - Salmela P
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Adrenal Gland Neoplasms/genetics
MH  - Chromosomes, Human/genetics
MH  - DNA, Neoplasm/*analysis
MH  - Female
MH  - Gene Dosage
MH  - Humans
MH  - Liver Neoplasms/genetics/secondary
MH  - Loss of Heterozygosity
MH  - Lymphatic Metastasis
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/diagnosis/*genetics/surgery
MH  - Nucleic Acid Hybridization
MH  - Parathyroid Neoplasms/genetics
MH  - Stomach Neoplasms/genetics
EDAT- 1998/09/02 00:00
MHDA- 1998/09/02 00:01
CRDT- 1998/09/02 00:00
PHST- 1998/09/02 00:00 [pubmed]
PHST- 1998/09/02 00:01 [medline]
PHST- 1998/09/02 00:00 [entrez]
AID - 10.1530/eje.0.1390202 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 1998 Aug;139(2):202-6. doi: 10.1530/eje.0.1390202.