PMID- 9724248
OWN - NLM
STAT- MEDLINE
DCOM- 19981005
LR  - 20220408
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 275
IP  - 3
DP  - 1998 Sep
TI  - Mechanisms of hepatic toxicity. I. TNF-induced liver injury.
PG  - G387-92
LID - 10.1152/ajpgi.1998.275.3.G387 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) functions as a two-edged sword in the 
      liver. TNF-alpha is required for normal hepatocyte proliferation during liver 
      regeneration. It functions both as a comitogen and to induce the transcription 
      factor nuclear factor-kappaB, which has antiapoptotic effects. On the other hand, 
      TNF-alpha is the mediator of hepatotoxicity in many animal models, including 
      those involving the toxins concanavalin A and lipopolysaccharide. TNF-alpha has 
      also been implicated as an important pathogenic mediator in patients with 
      alcoholic liver disease and viral hepatitis.
FAU - Bradham, C A
AU  - Bradham CA
AD  - Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 
      27599-7080, USA.
FAU - Plumpe, J
AU  - Plumpe J
FAU - Manns, M P
AU  - Manns MP
FAU - Brenner, D A
AU  - Brenner DA
FAU - Trautwein, C
AU  - Trautwein C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (NF-kappa B)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Hepatitis, Viral, Human/immunology/physiopathology
MH  - Humans
MH  - Liver/*pathology/physiology
MH  - Liver Diseases, Alcoholic/immunology/physiopathology
MH  - Liver Regeneration
MH  - Models, Biological
MH  - NF-kappa B/biosynthesis/genetics
MH  - Tumor Necrosis Factor-alpha/*physiology
RF  - 35
EDAT- 1998/09/02 00:00
MHDA- 1998/09/02 00:01
CRDT- 1998/09/02 00:00
PHST- 1998/09/02 00:00 [pubmed]
PHST- 1998/09/02 00:01 [medline]
PHST- 1998/09/02 00:00 [entrez]
AID - 10.1152/ajpgi.1998.275.3.G387 [doi]
PST - ppublish
SO  - Am J Physiol. 1998 Sep;275(3):G387-92. doi: 10.1152/ajpgi.1998.275.3.G387.