PMID- 972440
OWN - NLM
STAT- MEDLINE
DCOM- 19761203
LR  - 20091111
IS  - 0021-7263 (Print)
IS  - 0021-7263 (Linking)
VI  - 139
IP  - 3
DP  - 1976 Sep
TI  - The influence of ventricular function on the results of aortic valve replacement 
      for aortic stenosis.
PG  - 85-91
AB  - Thirty-three patients who had aortic valve replacement (AVR) for isolated aortic 
      stenosis (AS) were retrospectively evaluated to determine the influence of 
      preoperative ventricular function on the results of operation. Patients were 
      arbitrarily divided by ejection fraction (EF) into Group I having EF 0.46 or 
      above and Group II having EF 0.45 or below. Group II had significantly lower mean 
      EF and cardiac index and higher left ventricular end-diastolic volume index and 
      end-diastolic pressure. There were two early and no late deaths in 21 Group I 
      patients. There were no early and five late deaths in 12 Group II patients. All 
      Group I survivors and six of 12 Group II patients were New York Heart Association 
      (NYHA) functional Class I or II at follow-up evaluation. No preoperative 
      hemodynamic index was predictive of which Group II patients would do well. 
      Mortality was substantially higher in patients with severe preoperative 
      disability. Early or late death occurred in five of 12 patients who were NYHA 
      functional Class IV before operation but in only two of 21 patients who were 
      functional Class II or III preoperatively. We conclude that patients with 
      isolated AS and poor left ventricular function have a low hospital mortality but 
      an increased risk of late death or poor functional result following AVR. 
      Excellent functional results can be obtained after AVR in most patients with AS 
      and good left ventricular function and approximately half of the patients with AS 
      and poor left ventricular function.
FAU - Taw, R L Jr
AU  - Taw RL Jr
FAU - Pipkin, R
AU  - Pipkin R
FAU - Fortuin, N J
AU  - Fortuin NJ
FAU - Brawley, R K
AU  - Brawley RK
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Johns Hopkins Med J
JT  - The Johns Hopkins medical journal
JID - 0072456
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aortic Valve/*surgery
MH  - Aortic Valve Stenosis/mortality/physiopathology/*surgery
MH  - Cardiac Output
MH  - Cardiopulmonary Bypass
MH  - Female
MH  - Heart/physiopathology
MH  - Heart Valve Prosthesis/*mortality
MH  - *Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
EDAT- 1976/09/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1976/09/01 00:00
PHST- 1976/09/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1976/09/01 00:00 [entrez]
PST - ppublish
SO  - Johns Hopkins Med J. 1976 Sep;139(3):85-91.