PMID- 9726785
OWN - NLM
STAT- MEDLINE
DCOM- 19980916
LR  - 20191102
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 54
IP  - 8
DP  - 1998 Aug 21
TI  - Thermoregulation in rats exposed perinatally to dioxin: core temperature 
      stability to altered ambient temperature, behavioral thermoregulation, and 
      febrile response to lipopolysaccharide.
PG  - 647-62
AB  - Recent studies have shown that perinatal exposure to 
      2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) alters thermoregulatory 
      function in adult rats and hamsters, indicated by a reduced body temperature 
      during the animal's nocturnal phase. The present study was designed to assess the 
      behavioral thermoregulation, ability to develop a fever, and thermoregulatory 
      stability as a function of ambient temperature (Ta) in rats exposed perinatally 
      to TCDD. Pregnant Long-Evans rats were exposed on gestational day (GD) 15 to 1 
      microg TCDD/kg (po). The male offspring were implanted with transmitters to 
      monitor core temperature (Tc) and motor activity (MA). The 24-h pattern of core 
      temperature was affected by TCDD exposure, characterized by a reduced nocturnal 
      Tc. At some ages, the diurnal Tc of the TCDD group was elevated. This dysfunction 
      in temperature regulation was most apparent at 7 and 11 mo of age. The 24-h 
      pattern of MA was also altered by TCDD. The hypothermic effects of TCDD were most 
      pronounced at cooler Ta values of 10 to 22 degrees C. In contrast, behavioral 
      thermoregulation, assessed by measuring the selected Ta and Tc of rats in a 
      temperature gradient, was unaffected by TCDD. The ability to develop a fever 
      following administration of lipopolysaccharide (LPS) endotoxin (Escherichia coli; 
      50 microg/kg) was accentuated in the TCDD-treated animals. The data confirm a 
      nocturnal hypothermia in rats prenatally exposed to TCDD. However, the normal 
      behavioral regulation of Tc suggests that hypothalamic thermoregulatory centers 
      are not permanently altered. The accentuated fever in TCDD animals shows possible 
      functional alterations in the neuroimmune and/or thermoregulatory axes involved 
      in fever.
FAU - Gordon, C J
AU  - Gordon CJ
AD  - Neurotoxicology Division, National Health and Environmental Effects Research 
      Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North 
      Carolina 27711, USA. gordon@herl45.herl.epa.gov
FAU - Miller, D B
AU  - Miller DB
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Polychlorinated Dibenzodioxins)
SB  - IM
MH  - Administration, Oral
MH  - Age Factors
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Body Temperature Regulation/*drug effects
MH  - Female
MH  - Fever/*chemically induced
MH  - Lipopolysaccharides
MH  - Male
MH  - Motor Activity/drug effects
MH  - Polychlorinated Dibenzodioxins/administration & dosage/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Temperature
EDAT- 1998/09/03 00:00
MHDA- 1998/09/03 00:01
CRDT- 1998/09/03 00:00
PHST- 1998/09/03 00:00 [pubmed]
PHST- 1998/09/03 00:01 [medline]
PHST- 1998/09/03 00:00 [entrez]
AID - 10.1080/009841098158665 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 1998 Aug 21;54(8):647-62. doi: 
      10.1080/009841098158665.