PMID- 9728933
OWN - NLM
STAT- MEDLINE
DCOM- 19980917
LR  - 20061115
IS  - 0301-472X (Print)
IS  - 0301-472X (Linking)
VI  - 26
IP  - 10
DP  - 1998 Sep
TI  - Localization to chromosome 11 of a gene encoding a human minor histocompatibility 
      antigen.
PG  - 976-81
AB  - The graft-versus-host disease (GVHD) seen in human leukocyte antigen 
      (HLA)-matched sibling bone marrow transplants is by definition due to the "minor" 
      histocompatibility antigens (mHAs) encoded outside the HLA region of human 
      chromosome 6. Few of these antigens have been characterized in humans, and in 
      general the locations of the encoding loci are unknown. Genetic experiments 
      performed in mice have identified many mHAs, but only a few genes have been 
      identified. Using T lymphocyte clones reactive with specific mHAs, combined with 
      genetic linkage analysis, we identified two distinct loci in a single patient, 
      each locus encoding an antigen presented to a T cell clone by HLA-B7. The 
      technique used in this study should allow a rough enumeration of the number of 
      mHAs in humans that are capable of eliciting T cell responses in vivo. Whether 
      these T cell responses correlate with clinical GVHD is not yet clear.
FAU - Gubarev, M I
AU  - Gubarev MI
AD  - Department of Medicine, University of Utah School of Medicine, Salt Lake City 
      84132, USA.
FAU - Jenkin, J C
AU  - Jenkin JC
FAU - Otterrud, B E
AU  - Otterrud BE
FAU - Leppert, M F
AU  - Leppert MF
FAU - Schallheim, J M
AU  - Schallheim JM
FAU - Beatty, P G
AU  - Beatty PG
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Exp Hematol
JT  - Experimental hematology
JID - 0402313
RN  - 0 (HLA-B7 Antigen)
SB  - IM
MH  - Bone Marrow Transplantation/*immunology
MH  - *Chromosomes, Human, Pair 11
MH  - Genetic Code
MH  - Graft vs Host Disease/*immunology
MH  - HLA-B7 Antigen/*genetics
MH  - Humans
MH  - Lod Score
MH  - Male
MH  - *Minor Histocompatibility Loci
MH  - Pedigree
EDAT- 1998/09/05 00:00
MHDA- 1998/09/05 00:01
CRDT- 1998/09/05 00:00
PHST- 1998/09/05 00:00 [pubmed]
PHST- 1998/09/05 00:01 [medline]
PHST- 1998/09/05 00:00 [entrez]
PST - ppublish
SO  - Exp Hematol. 1998 Sep;26(10):976-81.