PMID- 9730013
OWN - NLM
STAT- MEDLINE
DCOM- 19981102
LR  - 20061115
IS  - 1078-0297 (Print)
IS  - 1078-0297 (Linking)
VI  - 100
IP  - 3
DP  - 1998 Jun
TI  - Docosahexaenoic acid inhibits blood viscosity in stroke-prone spontaneously 
      hypertensive rats.
PG  - 351-61
AB  - Increased blood viscosity facilitates the formation of thrombosis. This is an 
      important risk factor in the occurrence of cerebral infarctions. The present 
      study was undertaken to elucidate whether docosahexaenoic acid (DHA) inhibits 
      blood viscosity, hematocrit and fibrinogen in the disease animal model, 
      stroke-prone spontaneously hypertensive rats (SHRSP). An attempt was also made to 
      clarify the effect of DHA on blood pressure in SHRSP. Blood viscosity, hematocrit 
      and fibrinogen in non-treated SHRSP increased significantly when compared with 
      levels in age-matched non-treated Wistar Kyoto rats (WKY). SHRSP rats which were 
      administered DHA for 5 weeks displayed significant decreases in blood viscosity, 
      hematocrit and fibrinogen when compared with the values in non-treated SHRSP. The 
      blood pressure of DHA-treated SHRSP was significantly lower than that of 
      non-treated SHRSP. A positive correlation existed between blood pressure and 
      blood viscosity. These findings suggest that decreased blood viscosity induced by 
      DHA appears to be associated with the reduction of thrombosis formation and 
      hypotensive action in SHRSP.
FAU - Kimura, S
AU  - Kimura S
AD  - Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Health 
      Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.
FAU - Tamayama, M
AU  - Tamayama M
FAU - Minami, M
AU  - Minami M
FAU - Hata, N
AU  - Hata N
FAU - Saito, H
AU  - Saito H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Res Commun Mol Pathol Pharmacol
JT  - Research communications in molecular pathology and pharmacology
JID - 9437512
RN  - 0 (Antihypertensive Agents)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Antihypertensive Agents/pharmacology
MH  - Blood Pressure/drug effects
MH  - Blood Viscosity/*drug effects
MH  - Cerebrovascular Disorders/blood/*prevention & control
MH  - Docosahexaenoic Acids/*pharmacology
MH  - Fibrinogen/analysis
MH  - Hematocrit
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Thrombosis/blood/prevention & control
EDAT- 1998/09/08 00:00
MHDA- 1998/09/08 00:01
CRDT- 1998/09/08 00:00
PHST- 1998/09/08 00:00 [pubmed]
PHST- 1998/09/08 00:01 [medline]
PHST- 1998/09/08 00:00 [entrez]
PST - ppublish
SO  - Res Commun Mol Pathol Pharmacol. 1998 Jun;100(3):351-61.