PMID- 9730258
OWN - NLM
STAT- MEDLINE
DCOM- 19981204
LR  - 20190909
IS  - 0192-0561 (Print)
IS  - 0192-0561 (Linking)
VI  - 20
IP  - 4-5
DP  - 1998 Apr-May
TI  - Effect of Rehmannia glutinosa on immediate type allergic reaction.
PG  - 231-40
AB  - We investigated the effect of aqueous extract of Rehmannia glutinosa steamed root 
      (RGAE) on the allergic reactions in vivo and in vitro. RGAE dose-dependently 
      inhibited systemic allergic reaction induced by compound 48/80. When RGAE was 
      pre-treated at the same concentrations with systemic allergic reaction test, the 
      plasma histamine levels were reduced in a dose-dependent manner. RGAE 
      dose-dependently inhibited skin allergic reaction activated by anti-dinitrophenyl 
      (DNP) IgE. RGAE also dose-dependently inhibited the histamine release from the 
      rat peritoneal mast cells (RPMC) by compound 48/80 or anti-DNP IgE. Moreover, 
      RGAE had significant inhibitory effect on anti-DNP IgE-induced tumor necrosis 
      factor-alpha production of RPMC. These results indicate that RGAE may be 
      beneficial in the regulation of immediate type allergic reaction.
FAU - Kim, H
AU  - Kim H
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, 
      Chonbuk, South Korea. hmkim@med.wonkwang.ac.kr
FAU - Lee, E
AU  - Lee E
FAU - Lee, S
AU  - Lee S
FAU - Shin, T
AU  - Shin T
FAU - Kim, Y
AU  - Kim Y
FAU - Kim, J
AU  - Kim J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Immunopharmacol
JT  - International journal of immunopharmacology
JID - 7904799
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 820484N8I3 (Histamine)
RN  - Q13SKS21MN (2,4-Dinitrophenol)
SB  - IM
MH  - 2,4-Dinitrophenol/antagonists & inhibitors/pharmacology
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Histamine/blood
MH  - Histamine Release/drug effects
MH  - Hypersensitivity, Immediate/*drug therapy/immunology
MH  - Mast Cells/drug effects/metabolism
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Plant Extracts/pharmacology/therapeutic use
MH  - Plants, Medicinal/*chemistry
MH  - Rats
MH  - Tumor Necrosis Factor-alpha/pharmacology
MH  - p-Methoxy-N-methylphenethylamine/antagonists & inhibitors/pharmacology
EDAT- 1998/09/08 00:00
MHDA- 1998/09/08 00:01
CRDT- 1998/09/08 00:00
PHST- 1998/09/08 00:00 [pubmed]
PHST- 1998/09/08 00:01 [medline]
PHST- 1998/09/08 00:00 [entrez]
AID - S0192-0561(98)00037-X [pii]
AID - 10.1016/s0192-0561(98)00037-x [doi]
PST - ppublish
SO  - Int J Immunopharmacol. 1998 Apr-May;20(4-5):231-40. doi: 
      10.1016/s0192-0561(98)00037-x.