PMID- 9731015
OWN - NLM
STAT- MEDLINE
DCOM- 19981005
LR  - 20151119
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 158
IP  - 3
DP  - 1998 Sep
TI  - Contribution of HLA genes to genetic predisposition in diffuse panbronchiolitis.
PG  - 846-50
AB  - Diffuse panbronchiolitis (DPB) in East Asia is a distinctive chronic obstructive 
      pulmonary disease of unknown etiology. We hypothesize that the disease 
      susceptibility is due to genetic predisposition unique to Asians. Association 
      between human leukocyte antigen (HLA)-Bw54 and the disease was previously 
      reported. In the present study, using newly developed polymerase chain reaction 
      (PCR)- based methods, we directly analyzed HLA class I and II alleles in 76 
      Japanese patients. HLA-A, -B, and -C antigens were screened by the conventional 
      typing method, and then B22-group alleles including HLA-B54 were genotyped by 
      single-strand conformation polymorphism analysis. Alleles of HLA-DRB1 gene were 
      fully determined by the microtiter plate hybridization method. Thirty-seven 
      percent of the patients possessed HLA-B*5401 allele conserved predominantly in 
      East Asians, as compared with 15% of 110 healthy volunteers (chi2 = 12.4, p = 
      0.0004). In addition, 4% of the patients possessed B*5504 also unique to Asians 
      but a rare allele which was not found in normal control subjects in this study. 
      Typing of HLA-DRB1 class II gene did not demonstrate strong positive association 
      with the disease. A33, B44, and DRB1*1302 showed negative association with the 
      disease. We conclude that distinctive molecular structure of HLA-B alleles or a 
      closely linked gene in the HLA region contributes to genetic predisposition in 
      diffuse panbronchiolitis. This may partly explain why this disorder is found 
      primarily in Asians.
FAU - Keicho, N
AU  - Keicho N
AD  - Third Department of Internal Medicine, University of Tokyo; Department of Human 
      Genetics, Graduate School of Medical Sciences, University of Tokyo, Japan.
FAU - Tokunaga, K
AU  - Tokunaga K
FAU - Nakata, K
AU  - Nakata K
FAU - Taguchi, Y
AU  - Taguchi Y
FAU - Azuma, A
AU  - Azuma A
FAU - Bannai, M
AU  - Bannai M
FAU - Emi, M
AU  - Emi M
FAU - Ohishi, N
AU  - Ohishi N
FAU - Yazaki, Y
AU  - Yazaki Y
FAU - Kudoh, S
AU  - Kudoh S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*33 antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B22 antigen)
RN  - 0 (HLA-B44 Antigen)
RN  - 0 (HLA-B54 antigen)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Alleles
MH  - Biomarkers
MH  - Bronchiolitis/*genetics
MH  - Chi-Square Distribution
MH  - Female
MH  - Genetic Linkage/genetics
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-B44 Antigen
MH  - HLA-C Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Antigens Class I/genetics
MH  - Histocompatibility Antigens Class II/genetics
MH  - Humans
MH  - Japan
MH  - Lung Diseases, Obstructive/genetics
MH  - Male
MH  - Middle Aged
MH  - Molecular Structure
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single-Stranded Conformational
EDAT- 1998/09/10 00:00
MHDA- 1998/09/10 00:01
CRDT- 1998/09/10 00:00
PHST- 1998/09/10 00:00 [pubmed]
PHST- 1998/09/10 00:01 [medline]
PHST- 1998/09/10 00:00 [entrez]
AID - 10.1164/ajrccm.158.3.9712125 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 1998 Sep;158(3):846-50. doi: 
      10.1164/ajrccm.158.3.9712125.