PMID- 9731070
OWN - NLM
STAT- MEDLINE
DCOM- 19981006
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 92
IP  - 6
DP  - 1998 Sep 15
TI  - Acute mixed lineage leukemia with an inv(8)(p11q13) resulting in fusion of the 
      genes for MOZ and TIF2.
PG  - 2118-22
AB  - Chromosomal abnormalities in acute leukemia have led to the discovery of many 
      genes involved in normal hematopoiesis and in malignant transformation. We have 
      identified the fusion partners in an inv(8)(p11q13) from a patient with acute 
      mixed lineage leukemia. We show by fluorescence in situ hybridization (FISH) 
      analysis, Southern blotting, and reverse transcriptase-polymerase chain reaction 
      (RT-PCR) that the genes for MOZ, monocytic leukemia zinc finger protein, and 
      TIF2, transcriptional intermediary factor 2, are involved in the inv(8)(p11q13). 
      We demonstrate that the inversion creates a fusion between the 5' end of MOZ mRNA 
      and the 3' end of TIF2 mRNA maintaining the translational frame of the protein. 
      The predicted fusion protein contains the zinc finger domains, the nuclear 
      localization domains, the histone acetyltransferase (HAT) domain, and a portion 
      of the acidic domain of MOZ, coupled to the CREB-binding protein (CBP) 
      interaction domain and the activation domains of TIF2. The breakpoint is distinct 
      from the breakpoint in the t(8;16)(p11;p13) translocation in acute monocytic 
      leukemia with erythrophagocytosis that fuses MOZ with CBP. The reciprocal 
      TIF2-MOZ fusion gene is not expressed, perhaps as a result of a deletion near the 
      chromosome 8 centromere. The MOZ-TIF2 fusion is one of a new family of 
      chromosomal rearrangements that associate HAT activity, transcriptional 
      coactivation, and acute leukemia.
CI  - Copyright 1998 by The American Society of Hematology.
FAU - Liang, J
AU  - Liang J
AD  - Department of Molecular Biology and Biochemistry, Pediatrics, Urology, and 
      Medicine, the Feist-Weiller Cancer Center, Louisiana State University Medical 
      School, Shreveport, LA, USA.
FAU - Prouty, L
AU  - Prouty L
FAU - Williams, B J
AU  - Williams BJ
FAU - Dayton, M A
AU  - Dayton MA
FAU - Blanchard, K L
AU  - Blanchard KL
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (NCOA2 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Nuclear Receptor Coactivator 2)
RN  - 0 (Transcription Factors)
RN  - EC 2.3.1.- (Acetyltransferases)
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
RN  - EC 2.3.1.48 (KAT6A protein, human)
RN  - EC 2.7.7.49 (RNA-Directed DNA Polymerase)
SB  - IM
MH  - Acetyltransferases/biosynthesis/*genetics
MH  - Adult
MH  - Blotting, Southern
MH  - Chromosome Aberrations/diagnosis/*genetics
MH  - Chromosome Disorders
MH  - Chromosome Inversion
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Histone Acetyltransferases
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Biphenotypic, Acute/diagnosis/*genetics
MH  - Nuclear Proteins/biosynthesis/*genetics
MH  - Nuclear Receptor Coactivator 2
MH  - Polymerase Chain Reaction
MH  - RNA-Directed DNA Polymerase
MH  - Transcription Factors/biosynthesis/*genetics
MH  - Translocation, Genetic
EDAT- 1998/09/10 00:00
MHDA- 1998/09/10 00:01
CRDT- 1998/09/10 00:00
PHST- 1998/09/10 00:00 [pubmed]
PHST- 1998/09/10 00:01 [medline]
PHST- 1998/09/10 00:00 [entrez]
AID - S0006-4971(20)74082-6 [pii]
PST - ppublish
SO  - Blood. 1998 Sep 15;92(6):2118-22.