PMID- 9731591
OWN - NLM
STAT- MEDLINE
DCOM- 19980922
LR  - 20190727
IS  - 0039-2499 (Print)
IS  - 0039-2499 (Linking)
VI  - 29
IP  - 9
DP  - 1998 Sep
TI  - High prevalence of antiphosphatidylinositol antibodies in young patients with 
      cerebral ischemia of undetermined cause.
PG  - 1759-64
AB  - BACKGROUND AND PURPOSE: Anticardiolipin antibodies (aCL) are associated with 
      thrombotic phenomena including cerebral ischemia in young adults. Although aCL 
      are directed to a neoepitope formed by phospholipid and beta2-glycoprotein I 
      (beta2-GPI), immunoassays based on cardiolipin as target antigen are widely used. 
      We previously demonstrated that 47% of aCL-negative systemic lupus erythematosus 
      (SLE) patients had antiphospholipid antibodies (aPL) to epitopes other than 
      cardiolipin, and we found an association between aPL to noncardiolipin antigens 
      and thrombosis. We now assess the prevalence and clinical significance of 
      noncardiolipin aPL in young adults with cerebrovascular disease of undetermined 
      etiology. METHODS: Seventy-seven non-SLE patients, aged <51 years, with cerebral 
      ischemia were studied. Specificity of aPL were characterized by ELISAs using 7 
      different phospholipids: cardiolipin (CL), phosphatidylserine (PS), 
      phosphatidylinositol (PI), phosphatidylglycerol (PG), phosphatidic acid (PA), 
      phosphatidylcholine, and phosphatidylethanolamine. RESULTS: Thirty-four patients 
      (44.1%), had aPL to 1 or more of the following antigens: 23.4% to CL, 18.2% to 
      PS, 15.6% to PG, 14.3% to PA, and 28.6% to PI. Fifty-nine patients (76.6%) were 
      aCL negative. Of these subjects 23.4% showed aPL to noncardiolipin epitopes. PI 
      was the specificity with highest prevalence in all subgroups, and in 6 patients 
      anti-PI antibodies were the only detectable aPL. The binding of aPL to the 
      different antigens was beta2-GPI dependent. CONCLUSIONS: Our data demonstrate a 
      high prevalence of aPL in young adults with cerebral ischemia of undetermined 
      cause. PI was the specificity with highest prevalence, suggesting that anti-PI 
      antibodies may be an immunological marker in young patients with cerebrovascular 
      disease.
FAU - Toschi, V
AU  - Toschi V
AD  - Department of Hematology and Blood Transfusion, San Carlo Borromeo Hospital, 
      Milan, Italy. vitoschi@tin.it
FAU - Motta, A
AU  - Motta A
FAU - Castelli, C
AU  - Castelli C
FAU - Paracchini, M L
AU  - Paracchini ML
FAU - Zerbi, D
AU  - Zerbi D
FAU - Gibelli, A
AU  - Gibelli A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
RN  - 0 (Antibodies, Antiphospholipid)
RN  - 0 (Epitopes)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Phosphatidylinositols)
SB  - IM
CIN - Stroke. 1998 Sep;29(9):1755-8. PMID: 9731590
MH  - Adult
MH  - Age Factors
MH  - Antibodies, Antiphospholipid/*blood
MH  - Brain Ischemia/epidemiology/etiology/*immunology
MH  - Epitopes/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin A/blood
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - Male
MH  - Middle Aged
MH  - Phosphatidylinositols/*immunology
MH  - Prevalence
EDAT- 1998/09/10 00:00
MHDA- 1998/09/10 00:01
CRDT- 1998/09/10 00:00
PHST- 1998/09/10 00:00 [pubmed]
PHST- 1998/09/10 00:01 [medline]
PHST- 1998/09/10 00:00 [entrez]
AID - 10.1161/01.str.29.9.1759 [doi]
PST - ppublish
SO  - Stroke. 1998 Sep;29(9):1759-64. doi: 10.1161/01.str.29.9.1759.