PMID- 9732497
OWN - NLM
STAT- MEDLINE
DCOM- 19981210
LR  - 20161124
IS  - 0301-0449 (Print)
IS  - 0301-0449 (Linking)
VI  - 28
IP  - 9
DP  - 1998 Sep
TI  - Diagnostic imaging of primitive neuroectodermal tumour of the chest wall (Askin 
      tumour).
PG  - 697-702
AB  - OBJECTIVES: To describe the radiological features of primitive neuroectodermal 
      tumour (PNET) of the chest wall (Askin tumour) at diagnosis and to analyse the 
      radiological changes occurring as a consequence of treatment and during 
      follow-up. MATERIALS AND METHODS: Nine children with histologically proven PNET 
      were studied. At diagnosis, all patients underwent chest X-ray (CXR), chest CT 
      and bone scintigraphy; three patients also had MR and three had US. During 
      treatment and follow-up, CT was performed in all patients. RESULTS: CT 
      demonstrated a solid heterogeneous chest wall mass in all children at diagnosis 
      and six had a rib lesion. Small nodular densities in the extra-pleural fat were 
      identified in three patients at diagnosis. US, performed in three patients, 
      excluded tumour infiltration of the lung or diaphragm, which had been suspected 
      on CT. On MR, the lesions showed high signal intensity in 
      T1-weighted/proton-density images and intermediate/high signal intensity in 
      T2-weighted images compared with muscle. Minimal chest wall involvement was 
      demonstrated in one case by MRI. Extensive necrosis of tumour mass with 
      pseudo-cystic appearance was documented in the five patients who underwent 
      chemotherapy. Macroscopically complete resection was performed in five patients 
      but there was early local recurrence after surgery in two, identified by CT in 
      one and by MR in the other. CONCLUSIONS: PNET of the chest wall should be 
      considered in a child with a chest wall mass. CT is valuable for evaluating 
      tumour extension at diagnosis, the effects of chemotherapy and assessing tumour 
      recurrence after surgery. However, CT can overestimate pleural, lung or 
      diaphragmatic infiltration, which are better evaluated by US. MR was superior to 
      CT in the evaluation of tumour extension in one of three patients and may be 
      considered complementary to CT, particularly in very large chest wall tumours.
FAU - Sallustio, G
AU  - Sallustio G
AD  - Radiology Department, Catholic University of Rome, Largo A. Gemelli 8, I-00 168 
      Rome, Italy.
FAU - Pirronti, T
AU  - Pirronti T
FAU - Lasorella, A
AU  - Lasorella A
FAU - Natale, L
AU  - Natale L
FAU - Bray, A
AU  - Bray A
FAU - Marano, P
AU  - Marano P
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pediatr Radiol
JT  - Pediatric radiology
JID - 0365332
SB  - IM
MH  - Child
MH  - Humans
MH  - Sarcoma, Small Cell/*diagnostic imaging/pathology/therapy
MH  - Thoracic Neoplasms/*diagnostic imaging/pathology/therapy
MH  - Tomography, X-Ray Computed
EDAT- 1998/09/11 00:00
MHDA- 1998/09/11 00:01
CRDT- 1998/09/11 00:00
PHST- 1998/09/11 00:00 [pubmed]
PHST- 1998/09/11 00:01 [medline]
PHST- 1998/09/11 00:00 [entrez]
AID - 10.1007/s002470050443 [doi]
PST - ppublish
SO  - Pediatr Radiol. 1998 Sep;28(9):697-702. doi: 10.1007/s002470050443.