PMID- 9734366
OWN - NLM
STAT- MEDLINE
DCOM- 19980918
LR  - 20220409
IS  - 1097-2765 (Print)
IS  - 1097-2765 (Linking)
VI  - 2
IP  - 2
DP  - 1998 Aug
TI  - Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low 
      density lipoprotein receptor-deficient mice.
PG  - 275-81
AB  - Recruitment of blood monocytes into the arterial subendothelium is one of the 
      earliest steps in atherogenesis. Monocyte chemoattractant protein-1 (MCP-1), a CC 
      chemokine, is one likely signal involved in this process. To test MCP-1's role in 
      atherogenesis, low density lipoprotein (LDL) receptor-deficient mice were made 
      genetically deficient for MCP-1 and fed a high cholesterol diet. Despite having 
      the same amount of total and fractionated serum cholesterol as LDL 
      receptor-deficient mice with wild-type MCP-1 alleles, LDL 
      receptor/MCP-1-deficient mice had 83% less lipid deposition throughout their 
      aortas. Consistent with MCP-1 's monocyte chemoattractant properties, 
      compound-deficient mice also had fewer macrophages in their aortic walls. Thus, 
      MCP-1 plays a unique and crucial role in the initiation of atherosclerosis and 
      may provide a new therapeutic target in this disorder.
FAU - Gu, L
AU  - Gu L
AD  - Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, 
      USA.
FAU - Okada, Y
AU  - Okada Y
FAU - Clinton, S K
AU  - Clinton SK
FAU - Gerard, C
AU  - Gerard C
FAU - Sukhova, G K
AU  - Sukhova GK
FAU - Libby, P
AU  - Libby P
FAU - Rollins, B J
AU  - Rollins BJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (Chemokine CCL2)
RN  - 0 (DNA Primers)
RN  - 0 (Lipids)
RN  - 0 (Receptors, LDL)
SB  - IM
MH  - Animals
MH  - Aorta/metabolism/pathology
MH  - Arteriosclerosis/etiology/physiopathology/*prevention & control
MH  - Base Sequence
MH  - Cell Movement
MH  - Chemokine CCL2/*deficiency/genetics/physiology
MH  - DNA Primers/genetics
MH  - Diet, Atherogenic
MH  - Female
MH  - Lipid Metabolism
MH  - Lipids/blood
MH  - Macrophages/pathology/physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Monocytes/physiology
MH  - Polymerase Chain Reaction
MH  - Receptors, LDL/*deficiency
EDAT- 1998/09/12 00:00
MHDA- 1998/09/12 00:01
CRDT- 1998/09/12 00:00
PHST- 1998/09/12 00:00 [pubmed]
PHST- 1998/09/12 00:01 [medline]
PHST- 1998/09/12 00:00 [entrez]
AID - S1097-2765(00)80139-2 [pii]
AID - 10.1016/s1097-2765(00)80139-2 [doi]
PST - ppublish
SO  - Mol Cell. 1998 Aug;2(2):275-81. doi: 10.1016/s1097-2765(00)80139-2.