PMID- 9734708
OWN - NLM
STAT- MEDLINE
DCOM- 19980917
LR  - 20191210
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 63
IP  - 10
DP  - 1998
TI  - Hair analysis for drugs of abuse XX. Incorporation and behaviors of seven 
      methamphetamine homologs in the rat hair root.
PG  - 883-93
AB  - To elucidate drug disposition in hair, the incorporation and retention behavior 
      of 7 phenethylamines in the rat hair root were investigated: methamphetamine(MA), 
      3,4-methylenedioxymethamphetamine(MDMA), benzphetamine(BZP), ephedrine(EP), 
      N,N-dimethylamphetamine(DMA), p-nitro-methamphetamine(NO2MA), and 
      N-acetylmethamphetamine(AcMA). On day 10 after shaving the hair on the back of 
      the rats, drug was intraperitoneally administered at a single dose of 10 mg/kg to 
      Long Evans rats (which were male and 6 weeks of age), possessing black and white 
      hair, and the back hair that grew was collected by plucking with hair nippers at 
      0.083 h (5 min), 0.25 h, 0.5 h, 1 h, 2 h, 4 h, 6 h, 9 h, 24 h, 33 h and 48 h. 
      After washing the plucked hairs three times with 0.1% sodium dodecylsulfate, the 
      amount of drug in each of the hair root samples was analyzed by a selected ion 
      monitoring of gas chromatography mass spectrometry (GC-MS) analysis. The times at 
      which the concentration of each drug in the hair root samples reached the peak 
      concentration, ranged between 3.30 and 41.51 ng/mg. For each drug, the point of 
      time at which the largest positive incremental change in drug concentration was 
      seen, ranged between 5 min and 1 h, for all of the drugs except for AcMA which 
      was hardly incorporated in the rat hair. The data showed that there are mainly 4 
      modes in which a drug becomes incorporated into the black hair root: rapid and 
      prolonged incorporation (NO2MA, MDMA), rapid and short incorporation(MA, DMA), 
      slow and prolonged incorporation(BZP, EP), slow and short incorporation, which 
      includes hardly any incorporation (AcMA). As all seven drugs were hardly 
      incorporated into the white hair, it was concluded that the combination of 
      melanin and basic compounds is essential for a drug to become incorporated into 
      hair. Our results suggest that a portion of the drugs in the hair root is 
      accumulated in the hair shaft, and the remaining portion is redistributed outside 
      the hair shaft. The second finding is that the concentration of drug incorporated 
      into hair mainly depends on two processes--(1) the drug incorporation into hair 
      and the drug retention in hair.
FAU - Nakahara, Y
AU  - Nakahara Y
AD  - National Institute of Health Sciences, Setagaya, Tokyo, Japan.
FAU - Kikura, R
AU  - Kikura R
FAU - Takahashi, K
AU  - Takahashi K
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Illicit Drugs)
RN  - 0 (Pharmaceutical Preparations)
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Animals
MH  - Area Under Curve
MH  - Gas Chromatography-Mass Spectrometry
MH  - Hair Color/physiology
MH  - Illicit Drugs/*chemistry
MH  - Male
MH  - Methamphetamine/analogs & derivatives/*chemistry/pharmacokinetics
MH  - Pharmaceutical Preparations/*analysis
MH  - Rats
MH  - Substance Abuse Detection/*methods
EDAT- 1998/09/12 00:00
MHDA- 1998/09/12 00:01
CRDT- 1998/09/12 00:00
PHST- 1998/09/12 00:00 [pubmed]
PHST- 1998/09/12 00:01 [medline]
PHST- 1998/09/12 00:00 [entrez]
AID - S0024320598003452 [pii]
AID - 10.1016/s0024-3205(98)00345-2 [doi]
PST - ppublish
SO  - Life Sci. 1998;63(10):883-93. doi: 10.1016/s0024-3205(98)00345-2.