PMID- 9736136
OWN - NLM
STAT- MEDLINE
DCOM- 19980925
LR  - 20191210
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 136
IP  - 3
DP  - 1998 Sep
TI  - Does the 6-minute walk test predict the prognosis in patients with NYHA class II 
      or III chronic heart failure?
PG  - 449-57
AB  - BACKGROUND: We prospectively evaluated the potential of the 6-minute walk test 
      compared with peak VO2 in predicting outcome of patients with New York Heart 
      Association (NYHA) class II or III heart failure. METHODS AND RESULTS: Patients 
      with a history of heart failure caused by systolic dysfunction were included. The 
      combined final outcome (death or hospitalization for heart failure) was used as 
      the judgment criterion. One hundred twenty-one patients (age 59+/-11 years; left 
      ventricular ejection fraction 29.6%+/-13%) were included and followed for 
      1.53+/-0.98 years. Patients were separated into two groups according to outcome: 
      group 1 (G1, 74 patients), without events, and group 2 (G2, 47 patients), who 
      reached the combined end point. Peak VO2 was clearly different between G1 and G2 
      (18.5+/-4 vs. 13.9+/-4 ml/kg/min, p=0.0001) but not the distance walked (448+/-92 
      vs 410+/-126 m; p=0.084, not significant). Survival analysis showed that unlike 
      peak VO2, the distance covered was barely distinguishable between the groups (p < 
      0.08). However, receiver operating characteristic curves revealed that the best 
      performances for the 6-minute walk test were obtained for subjects walking < or 
      =300 m. These patients had a worse prognosis than those walking farther 
      (p=0.013). In this subset of patients, there was a significant correlation 
      between distance covered and peak VO2 (r=0.65, p=0.011). Thus it appears that the 
      more severely affected patients have a daily activity level relatively close to 
      their maximal exercise capacity. Nevertheless, the 300 m threshold suggested by 
      this study needs to be validated in an independent population. CONCLUSIONS: A 
      distance walked in 6 minutes < or =300 m can predict outcome. Moreover, in these 
      cases there is a significant correlation between the 6-minute walk test and peak 
      VO2 demonstrating the potential of this simple procedure as a first-line 
      screening test for this subset of patients.
FAU - Roul, G
AU  - Roul G
AD  - Cardiology Department, Hopitaux Universitaires de Strasbourg, Hopital de 
      Hautepierre, France.
FAU - Germain, P
AU  - Germain P
FAU - Bareiss, P
AU  - Bareiss P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
SB  - IM
CIN - Am Heart J. 1998 Sep;136(3):371-2. PMID: 9736125
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Cardiac Output, Low/classification/*diagnosis/diagnostic imaging
MH  - Confounding Factors, Epidemiologic
MH  - Exercise Test
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - ROC Curve
MH  - Radionuclide Imaging
MH  - Severity of Illness Index
MH  - Survival Analysis
MH  - *Walking
EDAT- 1998/09/15 00:00
MHDA- 1998/09/15 00:01
CRDT- 1998/09/15 00:00
PHST- 1998/09/15 00:00 [pubmed]
PHST- 1998/09/15 00:01 [medline]
PHST- 1998/09/15 00:00 [entrez]
AID - S0002870398001240 [pii]
AID - 10.1016/s0002-8703(98)70219-4 [doi]
PST - ppublish
SO  - Am Heart J. 1998 Sep;136(3):449-57. doi: 10.1016/s0002-8703(98)70219-4.