PMID- 9736676
OWN - NLM
STAT- MEDLINE
DCOM- 19981002
LR  - 20240216
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 18
IP  - 18
DP  - 1998 Sep 15
TI  - Phasic firing time locked to cocaine self-infusion and locomotion: dissociable 
      firing patterns of single nucleus accumbens neurons in the rat.
PG  - 7588-98
AB  - The activity of single nucleus accumbens (NAcc) neurons of rats was 
      extracellularly recorded during intravenous cocaine self-administration sessions 
      (0.7 mg/kg per infusion, fixed ratio 1). We reported previously that NAcc neurons 
      showed a change, usually a decrease, in firing rate during the first 1 min after 
      the cocaine-reinforced lever press. This postpress change was followed by a 
      progressive reversal of that change, which began within the first 2 min after the 
      press and was not complete until the last 1 min before the next lever press 
      (termed the change + progressive reversal firing pattern). In the present study 
      we documented a regular pattern of locomotion that occurred in parallel with the 
      change + progressive reversal firing pattern. This observation suggested that 
      discharges time locked to locomotion may determine the change + progressive 
      reversal firing pattern. However, 55% of the neurons failed to show firing time 
      locked to locomotion that could have contributed to the change + progressive 
      reversal firing pattern. Moreover, for all neurons, the change + progressive 
      reversal firing pattern was apparent even if the calculation of firing rate 
      excluded all periods of locomotion. The present data showed that the change + 
      progressive reversal firing pattern is not solely attributable to phasic changes 
      in firing time locked to the execution of locomotion. The change + progressive 
      reversal firing pattern closely mirrors changes in drug level and dopamine 
      overflow observed by previous researchers and may thus be a component of the 
      neurophysiological mechanism by which drug level regulates drug-taking behavior 
      during an ongoing self-administration session.
FAU - Peoples, L L
AU  - Peoples LL
AD  - Department of Psychology, Rutgers University, New Brunswick, New Jersey 08903, 
      USA.
FAU - Gee, F
AU  - Gee F
FAU - Bibi, R
AU  - Bibi R
FAU - West, M O
AU  - West MO
LA  - eng
GR  - R01 DA006886/DA/NIDA NIH HHS/United States
GR  - DA 06886/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Action Potentials/drug effects
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Cocaine/*pharmacology
MH  - Cocaine-Related Disorders/physiopathology
MH  - Dopamine Uptake Inhibitors/*pharmacology
MH  - Electrophysiology
MH  - Locomotion/*drug effects
MH  - Motivation
MH  - Neurons/*drug effects/physiology
MH  - Nucleus Accumbens/*cytology/drug effects/physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reaction Time/drug effects
MH  - Reward
MH  - Self Administration
MH  - Stereotyped Behavior/drug effects
PMC - PMC6793254
EDAT- 1998/09/16 00:00
MHDA- 1998/09/16 00:01
PMCR- 1999/03/15
CRDT- 1998/09/16 00:00
PHST- 1998/09/16 00:00 [pubmed]
PHST- 1998/09/16 00:01 [medline]
PHST- 1998/09/16 00:00 [entrez]
PHST- 1999/03/15 00:00 [pmc-release]
AID - 2341 [pii]
AID - 10.1523/JNEUROSCI.18-18-07588.1998 [doi]
PST - ppublish
SO  - J Neurosci. 1998 Sep 15;18(18):7588-98. doi: 10.1523/JNEUROSCI.18-18-07588.1998.