PMID- 9737302
OWN - NLM
STAT- MEDLINE
DCOM- 19980917
LR  - 20150616
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 352
IP  - 9130
DP  - 1998 Sep 5
TI  - Carcinoid tumour.
PG  - 799-805
AB  - Carcinoid tumours are often indolent asymptomatic tumours. However, a small but 
      significant proportion are malignant and difficult to manage. Multiple endocrine 
      neoplasia type 1 (MEN-1) may be associated with carcinoid tumours and should 
      therefore be considered in the investigation of these patients. This review puts 
      into context the use of newer imaging modalities, including octreotide 
      scintigraphy. The therapeutic treatment options are discussed, including the use 
      of octreotide, the role of receptor-targeted therapy, hepatic-artery 
      embolisation, and the arguments against chemotherapy. We review the need for 
      careful patient selection when considering curative and palliative surgery, 
      including liver transplantation. We conclude that there are now better diagnostic 
      tools and therapeutic options available for those patients with malignant 
      carcinoid tumours, and that these patients are best managed by a 
      multidisciplinary approach. Earlier detection and treatment of these tumours 
      should lead to improved quality of life and survival, which, ideally, should be 
      assessed in formal trials.
FAU - Caplin, M E
AU  - Caplin ME
AD  - Neuroendocrine Tumour Group and Clinic, Royal Free Hospital, London, UK. 
      caplin@rfhsm.ac.uk
FAU - Buscombe, J R
AU  - Buscombe JR
FAU - Hilson, A J
AU  - Hilson AJ
FAU - Jones, A L
AU  - Jones AL
FAU - Watkinson, A F
AU  - Watkinson AF
FAU - Burroughs, A K
AU  - Burroughs AK
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
CIN - Lancet. 1998 Nov 7;352(9139):1554. PMID: 9820330
CIN - Lancet. 1998 Nov 7;352(9139):1554. PMID: 9820331
CIN - Lancet. 1998 Nov 7;352(9139):1554-5. PMID: 9820332
MH  - *Carcinoid Tumor/chemistry/classification/pathology/physiopathology/therapy
MH  - Humans
RF  - 57
EDAT- 1998/09/16 00:00
MHDA- 1998/09/16 00:01
CRDT- 1998/09/16 00:00
PHST- 1998/09/16 00:00 [pubmed]
PHST- 1998/09/16 00:01 [medline]
PHST- 1998/09/16 00:00 [entrez]
AID - S0140-6736(98)02286-7 [pii]
AID - 10.1016/S0140-6736(98)02286-7 [doi]
PST - ppublish
SO  - Lancet. 1998 Sep 5;352(9130):799-805. doi: 10.1016/S0140-6736(98)02286-7.