PMID- 9737545
OWN - NLM
STAT- MEDLINE
DCOM- 19980925
LR  - 20190512
IS  - 0022-3069 (Print)
IS  - 0022-3069 (Linking)
VI  - 57
IP  - 9
DP  - 1998 Sep
TI  - Immunohistochemical localization of brain-derived neurotrophic factor in the 
      spinal cords of amyotrophic lateral sclerosis and non-amyotrophic lateral 
      sclerosis patients.
PG  - 822-30
AB  - Brain-derived neurotrophic factor (BDNF) has a trophic effect on several neuronal 
      subtypes including motor neurons. To localize and assess BDNF in the human spinal 
      cord with particular reference to amyotrophic lateral sclerosis (ALS), we 
      immunohistochemically studied spinal cords from 8 ALS and 13 non-ALS patients. 
      Punctate staining for BDNF was observed in neuronal somata and proximal processes 
      of large-sized anterior horn cells of non-ALS patients, as were distal axons 
      immunolabeled in the neuropil. The same immunostaining pattern was found in the 
      anterior horn cells of ALS patients. Neurons of the dorsal nucleus of Clarke, 
      intermediolateral nucleus, and posterior horn sensory system were also stained in 
      both groups. The results suggest that BDNF may act widely as a trophic factor in 
      the human spinal cord, and motor neurons in ALS patients might be sufficiently 
      supplied with endogenous BDNF from other neuronal subpopulations in the spinal 
      cord.
FAU - Kawamoto, Y
AU  - Kawamoto Y
AD  - Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
FAU - Nakamura, S
AU  - Nakamura S
FAU - Akiguchi, I
AU  - Akiguchi I
FAU - Kimura, J
AU  - Kimura J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Epitopes)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amyotrophic Lateral Sclerosis/metabolism/*pathology
MH  - Antibodies
MH  - Brain-Derived Neurotrophic Factor/*analysis
MH  - Epitopes/analysis/chemistry
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Nervous System Diseases/pathology
MH  - Reference Values
MH  - Spinal Cord/*pathology
EDAT- 1998/09/16 00:00
MHDA- 1998/09/16 00:01
CRDT- 1998/09/16 00:00
PHST- 1998/09/16 00:00 [pubmed]
PHST- 1998/09/16 00:01 [medline]
PHST- 1998/09/16 00:00 [entrez]
AID - 10.1097/00005072-199809000-00003 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 1998 Sep;57(9):822-30. doi: 
      10.1097/00005072-199809000-00003.