PMID- 9737658
OWN - NLM
STAT- MEDLINE
DCOM- 19980924
LR  - 20190512
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 113
IP  - 3
DP  - 1998 Sep
TI  - Autoantibodies to C-reactive protein (CRP) and other acute-phase proteins in 
      systemic autoimmune diseases.
PG  - 327-32
AB  - Autoantibodies to CRP were reported previously in patients suffering from toxic 
      oil syndrome. This syndrome resembles autoimmune diseases such as systemic lupus 
      erythematosus (SLE) or systemic scleroderma. We therefore examined the prevalence 
      of antibodies to CRP and other acute-phase proteins in autoimmune diseases, 
      including SLE, subacute cutaneous lupus erythematosus (SCLE), systemic 
      scleroderma (SSc), and primary biliary cirrhosis (PBC), as well as in bone marrow 
      transplantation-induced chronic graft-versus-host disease and 
      eosinophilia-myalgia syndrome. IgG antibodies to CRP were found in 78% of SLE and 
      in 30% of SCLE patients, while 16% of patients with PBC were positive. In up to 
      45% of patients with SSc predominantly IgG antibodies to ceruloplasmin were 
      detectable. Lack of systemic involvement as in discoid lupus erythematosus and 
      localized scleroderma (morphea) correlated with low or absent antibody formation. 
      However, no correlation was found between anti-acute-phase protein antibodies 
      with liver disease or other organ involvement. Adsorption studies revealed that 
      non-native epitopes on the CRP molecule, termed modified CRP, are the main target 
      of antibodies. Chronic inflammatory tissue injury in systemic autoimmune disease 
      might increase the presentation of cryptic epitopes of CRP to the threshold 
      required for T cell activation.
FAU - Bell, S A
AU  - Bell SA
AD  - Department of Dermatology, Ludwig-Maximilians-Universitat, Munchen, Germany.
FAU - Faust, H
AU  - Faust H
FAU - Schmid, A
AU  - Schmid A
FAU - Meurer, M
AU  - Meurer M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute-Phase Proteins/*immunology
MH  - Autoantibodies/*blood
MH  - Autoimmune Diseases/*immunology
MH  - C-Reactive Protein/*immunology
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Lupus Erythematosus, Systemic/immunology
MH  - Scleroderma, Systemic/immunology
PMC - PMC1905069
EDAT- 1998/09/16 00:00
MHDA- 1998/09/16 00:01
PMCR- 1999/09/01
CRDT- 1998/09/16 00:00
PHST- 1998/09/16 00:00 [pubmed]
PHST- 1998/09/16 00:01 [medline]
PHST- 1998/09/16 00:00 [entrez]
PHST- 1999/09/01 00:00 [pmc-release]
AID - 10.1046/j.1365-2249.1998.00655.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 1998 Sep;113(3):327-32. doi: 10.1046/j.1365-2249.1998.00655.x.